ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026
Migraine and the Risk of Dementia in the General Population.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
introductionMigraine and dementia are prevalent disorders with high societal impact; however, research regarding their association remains inconsistent.
methodsWe analyzed 6888 participants from the prospective Rotterdam Study. Migraine status was assessed (2006-2011) via validated questionnaire. Participants were followed for a median of 9.4 years until January 2020. Dementia diagnoses were confirmed through in-person screenings and medical record linkages, including neuroimaging.
resultsAt baseline, 1041 participants (15.1%) had migraine. Over 62,180 person-years, 491 participants developed dementia (379 [77.2%] with Alzheimer's). Cox models revealed that migraine was associated with a lower risk of dementia (hazard ratio [HR] 0.70, 95% confidence interval [CI]: 0.51-0.95) and Alzheimer's disease (HR 0.58, 95% CI: 0.40-0.85). DISCUSSION: This study suggests that migraine is associated with a reduced risk of dementia, including Alzheimer's disease. Whether this reflects biological neuroprotection or methodological factors is currently unclear, necessitating further investigation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.