Evidence map›Paper›PMID 42026634›Full record

ArticleJournal of radiation research2026

BMSCs alleviate inflammation and inhibit apoptosis in radiation pneumonitis treatment by modulating the NF-κB/NLRP3 signaling pathway.

Yiwei Song, Yuxin Wen, Huaqing Zhai, Na Zhang, Xu Tong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of radiation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yiwei SongThe Third Clinical Medical College, Qiqihar Medical University, No. 333 Bukui North Street, Jianhua District, Qiqihar 161006, China.
Yuxin WenCollege of Medical Technology, Qiqihar Medical University, No. 333 Bukui North Street, Jianhua District, Qiqihar 161006, China.
Huaqing ZhaiCollege of Medical Technology, Qiqihar Medical University, No. 333 Bukui North Street, Jianhua District, Qiqihar 161006, China.
Na ZhangDepartment of Radiation Oncology, The Third Affiliated Hospital of Qiqihar Medical University, No. 3, Taishun Street, Tiefeng District, Qiqihar 161000, China.
Xu TongDepartment of Radiation Oncology, The Third Affiliated Hospital of Qiqihar Medical University, No. 3, Taishun Street, Tiefeng District, Qiqihar 161000, China.

Funding

Construction Project of Dominant Characteristic Disciplines of Qiqihar Medical University QYZDXK-025, OncologyHeilongjiang Provincial Natural Science Foundation PL2024H261Qiqihar Medical University Postgraduate Innovation Fund QYYCX2023-59
6 · The paper itself

Abstract

Radiation pneumonitis (RP) is a severe consequence of thoracic radiation, and its pathophysiology is tightly linked to NLRP3 inflammasome-mediated hyperinflammatory reactions. The nuclear factor κB (NF-κB) signaling system, which regulates NLRP3, could be a potential therapeutic target. This study explores how bone marrow-derived mesenchymal stem cells (BMSCs) can treat RP via modifying the NF-κB/NLRP3 signaling pathway. BMSCs treatment significantly reduced inflammatory infiltration in rat lung tissue and decreased inflammatory cytokine release. Mechanistically, by inhibiting the NF-κB/NLRP3 signaling axis, BMSCs consequently reduce the secretion of key pro-inflammatory mediators, including IL-1β, IL-18, and TNF-α. Additionally, BMSCs suppressed apoptosis by downregulating inflammasome formation, achieving therapeutic effects against RP. BMSCs block NF-κB/NLRP3 signaling, reducing inflammasome production. They treat RP by inhibiting inflammasomes and suppressing apoptosis. This strategy is a novel therapy option for RP management and clinical prevention.

Indexed as

ApoptosisInflammationMesenchymal Stem CellsMesenchymal Stem Cell TransplantationNF-kappa BNLR Family, Pyrin Domain-Containing 3 ProteinRadiation PneumonitisSignal TransductionAnimalsInflammasomesMaleRatsRats, Sprague-DawleyInflammasomesNF-kappa BNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, ratapoptosisBMSCsinflammasomeNF-κB/NLRP3 signaling pathwayradiation pneumonitis

Identifiers

PMID42026634
PMCPMC13202319

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.