Evidence map›Paper›PMID 42026396›Full record

ArticleJournal of assisted reproduction and genetics2026

Likelihood of obtaining a usable embryo for transfer after IVF with PGT-A and PGT-M for variants in two genes.

Melody A Rasouli, Lisette Collins, Mabel Lee, Rachel Martel, Mehrnaz Siavoshi, Lorna Kwan, Jenna Miller, Chelsea Woody, Robert Roman, Lindsay Kroener

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Article in Journal of assisted reproduction and genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Melody A RasouliDepartment of Obstetrics and Gynecology, University of California, Los Angeles, Los Angeles, United States. mrasouli@mednet.ucla.edu.
Lisette CollinsDepartment of Obstetrics and Gynecology, University of California, Los Angeles, Los Angeles, United States.
Mabel LeeDepartment of Obstetrics and Gynecology, University of California, Los Angeles, Los Angeles, United States.
Rachel MartelDepartment of Obstetrics and Gynecology, University of California, Los Angeles, Los Angeles, United States.
Mehrnaz SiavoshiDepartment of Urology, University of California, Los Angeles, Los Angeles, United States.
Lorna KwanDepartment of Urology, University of California, Los Angeles, Los Angeles, United States.
Jenna MillerCooper Genomics, Livingston, United States.
Chelsea WoodyCooper Genomics, Livingston, United States.
Robert RomanDepartment of Obstetrics and Gynecology, University of California, Los Angeles, Los Angeles, United States.
Lindsay KroenerDepartment of Obstetrics and Gynecology, University of California, Los Angeles, Los Angeles, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo determine the likelihood of obtaining at least one transferable embryo per cycle in patients undergoing IVF with PGT-A + PGT-M for variants in one versus two genes.

methodsIVF cycles in patients 18-45 years undergoing PGT-A + PGT-M for variants in one or two genes at a single genetics laboratory were analyzed from 11/2019 to 3/2023. Cycles were stratified by SART age category and disease inheritance pattern. Analyses were performed using median and chi-square tests.

resultsA total of 4634 IVF cycles were included: 146 cycles (3.15%) using PGT-A + PGT-M for two genes and 4488 cycles (96.85%) for one gene. After adjusting for the number of embryos biopsied, the likelihood of having at least one usable embryo was significantly lower in patients testing for variants in two genes compared to one in patients aged < 35 (75.0% v 82.5%, p = 0.004) and 35-37 (55.0% v 74.4%, p = 0.025) with no difference in other age groups 38-40 (66.7% v 74.4%, p = 0.586) and 41-42 (42.9% v 51.7%, p = 0.113).

conclusionsThere were significantly lower odds of obtaining a usable embryo when testing for variants in genes in patients aged < 35 and 35-37. No significant difference was seen among patients aged 38-40 or 41-42. These findings provide quantifiable data to counsel patients considering PGT-M testing for variants in two genes.

Indexed as

Embryo TransferFertilization in VitroGenetic TestingPreimplantation DiagnosisAdolescentAdultFemaleHumansMiddle AgedPregnancyPregnancy RateIn vitro fertilizationMonogenic disordersPGT-APGT-MPreimplantation genetic testing

Identifiers

PMID42026396
PMCPMC13319311

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