Evidence map›Paper›PMID 42026378›Full record

ArticleJournal of mathematical biology2026

Theory and simulations of delayed stochastic and deterministic models of prion diseases.

Gangadhara Boregowda, Omar Sharif, Daniel Gutierrez Iii, Allegra Simmons, Laurent Pujo-Menjouet, Tamer Oraby, Michael R Lindstrom

Abstract read
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In one paragraph

Article in Journal of mathematical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gangadhara BoregowdaSchool of Mathematical and Statistical Sciences, The University of Texas Rio Grande Valley, Edinburg, Texas, USA. gangadhara.boregowda@utrgv.edu.
Omar SharifSchool of Mathematical and Statistical Sciences, The University of Texas Rio Grande Valley, Edinburg, Texas, USA.
Daniel Gutierrez IiiSchool of Mathematical and Statistical Sciences, The University of Texas Rio Grande Valley, Edinburg, Texas, USA.
Allegra SimmonsDepartment of Mathematics, The University of Dallas, Irving, Texas, USA.
Laurent Pujo-MenjouetDepartment of Mathematics, Universite Claude Bernard Lyon 1, CNRS, Centrale de Lyon, INSA Lyon, Université Jean Monnet, ICJ UMR5208, Inria, 69622, Villeurbanne, France.
Tamer OrabySchool of Mathematical and Statistical Sciences, The University of Texas Rio Grande Valley, Edinburg, Texas, USA.
Michael R LindstromSchool of Mathematical and Statistical Sciences, The University of Texas Rio Grande Valley, Edinburg, Texas, USA.

Funding

Agence National de la Recherche ANR-21-CE15-0011National Science Foundation 2150478National Science Foundation 2316952
6 · The paper itself

Abstract

Neurodegenerative diseases (NDs), such as Alzheimer's, Parkinson's, and prion diseases, are characterized by the dynamical spread of toxic proteins through the brain. In prion diseases, cellular prion protein (

Indexed as

Models, BiologicalPrion DiseasesAnimalsBrainComputer SimulationDisease ProgressionHumansMathematical ConceptsPrionsPrPC ProteinsPrPSc ProteinsStochastic ProcessesPrionsPrPC ProteinsPrPSc ProteinsDelayed stochastic differential equationExtinction-persistenceGlobal existence-uniquenessHopf bifurcationPrion diseaseUnfolded Protein Response

Identifiers

PMID42026378
PMCPMC13106245

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.