ArticleNature cardiovascular research2026
Therapeutic Spp1 silencing in TREM2
Abstract read
In one paragraph
Article in Nature cardiovascular research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Macrophage heterogeneity in organ fibrosis in the era of single-cell omics.Molecular biology reports · 2026Review
- Unleashing innovative cross-organ fibrosis therapies by harnessing the omics revolution.JCI insight · 2026Review
- Single-Cell dissection of fibrodysplasia ossificans progressiva identifies SPP1 as a mediator of macrophage-fibroadipogenic progenitors crosstalk.Cellular and molecular life sciences : CMLS · 2026Article
- Osteopontin in Atrial Fibrillation and Atrial Remodeling.Journal of the American Heart Association · 2026Review
- Antibody-siRNA conjugates enable macrophage-specific osteopontin inhibition to suppress atrial fibrillation.Nature cardiovascular research · 2026Article
- Macrophages of the heart: Homeostasis and disease.Biomedical journal · 2026Review
- Interstitial cells and arrhythmia.American journal of physiology. Cell physiology · 2026Review
- More than myocytes: The heart's electrical ensemble.The Journal of physiology · 2026Article
- Vagal Stimulation Rescues HFpEF by Altering Cardiac Resident Macrophage Function.Circulation research · 2025Article
- Atrial Fibrillation in Diabetes: Pathogenesis and Targeted Rhythm Control Strategies.Current issues in molecular biology · 2025Review
- Review
- New Insights into the Role of Inflammatory Pathways and Immune Cell Infiltration in Sleep Deprivation-Induced Atrial Fibrillation: An Integrated Bioinformatics and Experimental Study.Journal of inflammation research · 2025Article
- Genetic and Molecular Underpinnings of Atrial Fibrillation.NPJ cardiovascular health · 2024Article
Corrections and comments
- Update ofTherapeutic2024
Authors and funding
29 authors.
Noor Momin *Center for Systems Biology, Mass General Brigham and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-3145-6089
Steffen Pabel *Center for Systems Biology, Mass General Brigham and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0009-0000-1121-4889
Arnab RudraDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-1704-5534
Nina KumowskiCenter for Systems Biology, Mass General Brigham and Harvard Medical School, Boston, MA, USA.
I-Hsiu LeeCenter for Systems Biology, Mass General Brigham and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7200-7867
Hana SeungCenter for Systems Biology, Mass General Brigham and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0009-0004-7754-787X
Kyle I MentkowskiCenter for Systems Biology, Mass General Brigham and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-6623-2096
Aneesh BapatCardiovascular Research Center, Mass General Brigham and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-1996-522X
Masahiro YamazoeCenter for Systems Biology, Mass General Brigham and Harvard Medical School, Boston, MA, USA.
Laura StengelDepartment of Internal Medicine II, University Medical Center Regensburg, Regensburg, Germany.ORCID http://orcid.org/0009-0004-8940-3515
Charlotte G MuseCenter for Systems Biology, Mass General Brigham and Harvard Medical School, Boston, MA, USA.
Alexandre PaccaletCenter for Systems Biology, Mass General Brigham and Harvard Medical School, Boston, MA, USA.
Farid F KadyrovCenter for Systems Biology, Mass General Brigham and Harvard Medical School, Boston, MA, USA.
Cristina González-CorreaCenter for Systems Biology, Mass General Brigham and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-0828-6598
Emily JacobsDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0009-0006-6158-1488
Ellie FengDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0009-0002-4900-4814
Jisoo ParkDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0009-0007-3412-9557
Jana GruneCenter for Systems Biology, Mass General Brigham and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-6209-7416
Maximilian J SchlossCenter for Systems Biology, Mass General Brigham and Harvard Medical School, Boston, MA, USA.
Samuel SossallaDepartment of Cardiology, University Hospital Giessen, Kerckhoff Clinic Bad Nauheim, and DZHK, Partner site RhineMain, Germany.ORCID http://orcid.org/0000-0001-8034-2673
Gregory WojtkiewiczCenter for Systems Biology, Mass General Brigham and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-3148-8411
Yoshiko IwamotoCenter for Systems Biology, Mass General Brigham and Harvard Medical School, Boston, MA, USA.
Patrick McMullenDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Richard N MitchellDepartment of Pathology, Mass General Brigham and Harvard Medical School, Boston, MA, USA.
Patrick T EllinorCardiovascular Research Center, Mass General Brigham and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-2067-0533
Daniel G AndersonDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0001-5629-4798
Kamila NaxerovaCenter for Systems Biology, Mass General Brigham and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7744-5110
Matthias NahrendorfCenter for Systems Biology, Mass General Brigham and Harvard Medical School, Boston, MA, USA. mnahrendorf@mgh.harvard.edu.ORCID http://orcid.org/0000-0002-4021-1887
Maarten HulsmansCenter for Systems Biology, Mass General Brigham and Harvard Medical School, Boston, MA, USA. mhulsmans@mgh.harvard.edu.ORCID http://orcid.org/0000-0003-1009-658X
Funding
PROJECT 4: Somatic evolution of the hematopoietic system in cardiovascular diseaseP01HL142494 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Matthias Nahrendorf · 2019 to 2026
$19.5MTraining Grant in Molecular Imaging Research (MGH/HMS)T32CA079443 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI WEISSLEDER, MD, PHD, RALPH · 2000 to 2025
$10.1MImaging organ system interfaces in ischemic heart diseaseR35HL139598 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NAHRENDORF, MATTHIAS · 2018 to 2024
$6.9MCardiac resident macrophages in AV node conductionR01HL149647 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI HULSMANS, MAARTEN · 2022 to 2025
$2.9MMacrophage heterogeneity in atrial remodelingR01HL155097 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI HULSMANS, MAARTEN · 2021 to 2025
$2.9MMacrophages in Cardiovascular HealthR35HL176359 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Matthias Nahrendorf · 2025 to 2026
$2.2MWNT Signaling in the Pathogenesis of Atrial FibrillationK08HL171874 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Aneesh Bapat · 2024 to 2026
$511kDeutsche Forschungsgemeinschaft (German Research Foundation) 530157297Deutsche Forschungsgemeinschaft (German Research Foundation) GR 5261/1-1Deutsche Forschungsgemeinschaft (German Research Foundation) SFB 1470-A04Deutsche Forschungsgemeinschaft (German Research Foundation) SO 1223/4-1Deutsche Forschungsgemeinschaft (German Research Foundation) SO 1223/6-1NCI NIH HHS T32 CA079443NHLBI NIH HHS K08 HL171874NHLBI NIH HHS P01 HL142494NHLBI NIH HHS R01 HL149647NHLBI NIH HHS R01 HL155097NHLBI NIH HHS R35 HL139598NHLBI NIH HHS R35 HL176359Thoracic Surgery Foundation (TSF) GR1001261U.S. Department of Health & Human Services | National Institutes of Health (NIH) HL139598U.S. Department of Health & Human Services | National Institutes of Health (NIH) HL142494U.S. Department of Health & Human Services | National Institutes of Health (NIH) HL149647U.S. Department of Health & Human Services | National Institutes of Health (NIH) HL155097U.S. Department of Health & Human Services | National Institutes of Health (NIH) T32CA079443
Abstract
Atrial fibrillation and the risk of its lethal complications are propelled by fibrosis, which induces electrical heterogeneity and gives rise to reentry circuits. Atrial TREM2
Indexed as
Atrial FibrillationMacrophagesMembrane GlycoproteinsOsteopontinReceptors, ImmunologicRNA InterferenceRNA, Small InterferingAnimalsDisease Models, AnimalFibrosisGene SilencingHeart AtriaHumansMaleMiceMice, Inbred C57BLMembrane GlycoproteinsOsteopontinReceptors, ImmunologicRNA, Small InterferingSPP1 protein, humanSpp1 protein, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.