ArticleThe AAPS journal2026
Quantitative Investigation of ATP Switch Concept of STA551 Through Combined In Vivo Tissue Distribution Studies and Physiologically Based Pharmacokinetic Modeling.
Article in The AAPS journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
STA551 is an anti-human CD137 (hCD137) switch antibody with adenosine triphosphate (ATP)-dependent antigen binding, developed to achieve potent anti-tumor effects and superior safety. Based on several reports, unlike in normal tissues, high concentrations of ATP are considered to exist in the interstitial space of tumors, thus STA551 is expected to exhibit tumor-selective antigen (hCD137) binding (ATP switch concept). This study aims to quantitatively investigate this ATP switch concept in vivo by combining tissue distribution studies and physiologically based pharmacokinetic (PBPK) modeling. An iodinated conventional anti-hCD137 antibody,
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