ArticlePsychopharmacology2026
Reproductive experience modifies the dopaminergic system of postpartum estrous rats: changes in the sensitivity to the behavioural effects of sch-23390 and in its receptors' binding.
Article in Psychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationalePostpartum estrous (PPE) rats are able to care for their litter and copulate with a male, however when given the choice, they prefer their pups over males. This preference is stronger in multiparous rats than in primiparous rats, indicating that previous reproductive experience increases their maternal motivation. Dopaminergic neurotransmission, particularly that acting on D1-like receptors in the Nucleus Accumbens (NAcc) and the medial Preoptic Area (mPOA), has been implicated in controlling maternal motivation and maternal behavior execution.
objectiveDetermining whether the dopaminergic system differs between primiparous and multiparous PPE rats.
methodsTwo approaches were employed: 1) determining the effect of systemic administration of the selective D1-like receptors antagonist SCH-23390 (at 0.0, 0.025, and 0.05 mg/kg doses) on maternal behavior execution and locomotion, and 2) determining D1- and D2-like receptors binding in the NAcc, dorsal striatum, medial prefrontal cortex, and mPOA of primiparous and multiparous PPE rats.
resultsSCH-23390 reduced the active components of maternal behavior and locomotor activity in PPE rats, with the lower dose of this D1-like receptors antagonist having greater effects in multiparous females. Compared to primiparous females, multiparous rats also exhibited increased binding to the D1-like receptors antagonist [3H]-SCH-23390 in NAcc and dorsal striatum and reduced binding to the D2-like receptors antagonist [3H]-nemonapride in the NAcc shell.
conclusionsThese findings demonstrate that prior reproductive experience alters the behavioral sensitivity to SCH-23390 and its binding in the striatum of PPE rats.
Indexed as
Identifiers
42026311What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.