ReviewNature cell biology2026
A lipid-centric view of endocytosis by caveolae.
Review in Nature cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Quantification of lipid sorting during clathrin-mediated endocytosis.Nature cell biology · 2026Article
- Article
- Caveolin-1 in atherosclerosis: from endothelial lipoprotein transport to vascular immunometabolic remodeling.Frontiers in cardiovascular medicine · 2026Review
- From seeds to symptoms: the molecular landscape of tau seeding in Alzheimer's disease.Frontiers in neuroscience · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Caveolae have long been considered to be an alternative endocytic pathway, with distinct cargoes, but generally similar functions, to clathrin-coated pits. Here we suggest that the mechanisms of caveola formation and their scission are tightly interlinked and rely on specific lipids. These mechanisms are fundamentally different to those driving the formation and fission of coated pits. Both formation and scission of caveolae are driven by lipid-induced shaping of the caveolar domain, and we present biophysical models for lipid-driven curvature generation and its coupling with scission. In addition, we propose that these new insights have important implications for understanding the function of endocytosis mediated by caveolae. Rather than a parallel endocytic pathway for protein cargo, we argue that caveolae are a lipid-sensitive mobilized multifunctional surface domain.
Indexed as
Identifiers
42026115What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.