Evidence map›Paper›PMID 42026047›Full record

ArticleNature communications2026

Assessing the contribution of rare DNA states to cancer mutational signatures using sequence-specific conformational fingerprinting.

Or Szekely, Yeongjoon Lee, Atul K Rangadurai, Serafima Guseva, Joshua Cooksey, Edgar M Faison, Nikita Zalenski, Qi Zhang, Zucai Suo, Hashim M Al-Hashimi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Or SzekelyDepartment of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. or_szekely@med.unc.edu.ORCID http://orcid.org/0000-0002-9502-9337
Yeongjoon LeeDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.
Atul K RangaduraiDepartment of Biochemistry, Duke University School of Medicine, Durham, NC, USA.
Serafima GusevaDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.
Joshua CookseyDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.ORCID http://orcid.org/0009-0004-5787-6502
Edgar M FaisonDepartment of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0003-0207-767X
Nikita ZalenskiDepartment of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, FL, USA.ORCID http://orcid.org/0009-0001-8339-8100
Qi ZhangDepartment of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0003-1754-4058
Zucai SuoDepartment of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, FL, USA.ORCID http://orcid.org/0000-0003-3871-3420
Hashim M Al-HashimiDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA. ha2639@cumc.columbia.edu.ORCID http://orcid.org/0000-0003-0681-1747

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
RM1 Center on Macromolecular Dynamics by NMR Spectroscopy at the New York Structural Biology Center (CoMD/NMR)- Equipment Supplement RequestRM1GM145397 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI ARTHUR G PALMER · 2022 to 2026
$8.3M
Role of DNA structural dynamics in mutagenesis and oncogenesisR01GM089846 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Hashim M Al-Hashimi · 2010 to 2026
$5.2M
Riboswitch Dynamics at Atomic ResolutionR01GM114432 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ZHANG, QI · 2015 to 2024
$3.0M
475 MHz NMR SpectrometerS10OD023499 · OD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PALMER, ARTHUR G · 2017 to 2017
$925k
Upgrade of 800 MHz SpectrometerS10OD016432 · OD · NEW YORK STRUCTURAL BIOLOGY CENTER · PI PALMER, ARTHUR G · 2014 to 2014
$600k
Acquisition of an 800 MHz TXO CryoProbeS10OD028577 · OD · NEW YORK STRUCTURAL BIOLOGY CENTER · PI PALMER, ARTHUR G · 2020 to 2020
$299k
NCI NIH HHS P30 CA016086NIGMS NIH HHS R01 GM089846NIGMS NIH HHS R01 GM114432NIGMS NIH HHS RM1 GM145397NIH HHS S10 OD016432NIH HHS S10 OD023499NIH HHS S10 OD028577U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R01GM089846Weizmann Institute of Science Women's Postdoctoral Career Development Award
6 · The paper itself

Abstract

Rare and short-lived DNA conformations are proposed to be key drivers of mutagenesis, yet assessing their contribution to mutational signatures found in human cancers remains challenging. Here, we develop an approach that quantifies the sequence-dependent propensity to form a rare DNA conformation and compare the resulting fingerprint against cancer mutational signatures. Using

Indexed as

DNAMutationNeoplasmsNucleic Acid ConformationHumansDNA

Identifiers

PMID42026047
PMCPMC13315743

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.