ArticleNature communications2026
Molecular mechanisms of native ligand selectivity in catecholamine G protein-coupled receptors.
Nour Aldin Kahlous, Maiju K Rinne, Xin Zhang, Yanying Li, Yue Chen, Aikaterini Motso, Kaixuan Gao, Christina Bergqvist, Hongda Sheng, Yi Wang and 11 more
Abstract read
In one paragraphArticle in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
21 authors.
Nour Aldin Kahlous *Science for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden.ORCID 0000-0002-7744-1491 Xin Zhang *State Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, China.
Yanying LiDepartment of Medical Cell Biology, Uppsala University, Uppsala, Sweden.
Yue ChenScience for Life Laboratory, Department of Applied Physics, KTH Royal Institute of Technology, Stockholm, Sweden.
Aikaterini MotsoDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Kaixuan GaoState Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, China.
Christina BergqvistDepartment of Medical Cell Biology, Uppsala University, Uppsala, Sweden.
Hongda ShengDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Israel Cabeza de VacaScience for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden.ORCID 0000-0002-6208-1091 Alejandro Díaz-HolguínScience for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden.ORCID 0000-0002-3449-5086 Philip UllmannScience for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden.ORCID 0000-0003-2391-4609 Tore BengtssonDepartment of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.ORCID 0000-0002-5396-030X Volker M LauschkeDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-1140-6204 Lucie DelemotteScience for Life Laboratory, Department of Applied Physics, KTH Royal Institute of Technology, Stockholm, Sweden.ORCID 0000-0002-0828-3899 Xiangyu LiuState Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, China. liu_xy@mail.tsinghua.edu.cn.ORCID 0000-0003-3178-9238 Dan LarhammarDepartment of Medical Cell Biology, Uppsala University, Uppsala, Sweden. dan.larhammar@uu.se.ORCID 0000-0002-6736-0663 Jens CarlssonScience for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden. jens.carlsson@icm.uu.se.ORCID 0000-0003-4623-2977 Funding
Knut och Alice Wallenbergs Stiftelse (Knut and Alice Wallenberg Foundation) 2019.0130
6 · The paper itselfAbstract
Activation of G protein-coupled receptors (GPCRs) by extracellular ligands is crucial for cellular communication and modulates numerous physiological processes. Despite sharing highly similar orthosteric binding sites, catecholamine GPCRs exhibit exquisite selectivity for their native agonists, even among nearly identical chemical messengers. However, the molecular basis and evolution of receptor selectivity remain poorly understood. To elucidate the structural mechanisms of GPCR selectivity, we focus on the prototypical human β
Indexed as
CatecholaminesReceptors, Adrenergic, beta-2Receptors, Dopamine D1Receptors, G-Protein-CoupledAmino Acid SequenceBinding SitesCryoelectron MicroscopyHumansLigandsModels, MolecularProtein BindingCatecholaminesLigandsReceptors, Adrenergic, beta-2Receptors, Dopamine D1Receptors, G-Protein-Coupled
Identifiers
PMID42026038
PMCPMC13150006
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