Evidence map›Paper›PMID 42026015›Full record

ArticlePsycho-oncology2026

Impact of Spiritual Wellbeing in Advanced Cancer Patients Receiving Genomic Test Results.

Megan C Best, Joseph Descallar, Grahame Simpson, Christine E Napier, Nicci Bartley, Mandy L Ballinger, David Goldstein, David M Thomas, Katherine M Tucker, Phyllis Butow

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psycho-oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Megan C BestUniversity of Notre Dame Australia, Institute for Ethics and Society, Sydney, NSW, Australia.ORCID https://orcid.org/0000-0003-1570-8872
Joseph DescallarIngham Institute for Applied Medical Research, Liverpool, NSW, Australia.ORCID https://orcid.org/0000-0002-6919-4865
Grahame SimpsonIngham Institute for Applied Medical Research, Liverpool, NSW, Australia.ORCID https://orcid.org/0000-0001-8156-9060
Christine E NapierCentre for Molecular Oncology, Faculty of Medicine & Health, University of NSW, Sydney, NSW, Australia.ORCID https://orcid.org/0000-0001-8009-7735
Nicci BartleyPsycho-Oncology Co-Operative Research Group (PoCoG), University of Sydney, Sydney, NSW, Australia.ORCID https://orcid.org/0000-0001-9052-1616
Mandy L BallingerCentre for Molecular Oncology, Faculty of Medicine & Health, University of NSW, Sydney, NSW, Australia.ORCID https://orcid.org/0000-0002-9706-0514
David GoldsteinFaculty of Medicine & Health, University of NSW, Sydney, NSW, Australia.ORCID https://orcid.org/0000-0001-6142-3291
David M ThomasCentre for Molecular Oncology, Faculty of Medicine & Health, University of NSW, Sydney, NSW, Australia.ORCID https://orcid.org/0000-0002-2527-5428
Katherine M TuckerPrince of Wales Medical School, Hereditary Cancer Centre, University of New South Wales, Prince of Wales Hospital, Randwick, NSW, Australia.ORCID https://orcid.org/0000-0002-7180-6576
Phyllis ButowPsycho-Oncology Co-Operative Research Group (PoCoG), University of Sydney, Sydney, NSW, Australia.ORCID https://orcid.org/0000-0003-3562-6954

Funding

PROJECT 3: Applying Liquid Biopsy Technologies to Detect Clinical Response and Mechanisms of Resistance in the Treatment of LMSP50CA272170 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JUDY E. GARBER · 2022 to 2026
$13.3M
Cancer Institute NSWNational Health and Medical Research Council 1124749NCI NIH HHS P50 CA272170
6 · The paper itself

Abstract

objectiveLittle is known about the impact of treatment availability on the spiritual wellbeing of advanced cancer patients. The aim of this study was to examine the relationships between spiritual wellbeing and patient anxiety, depression, hope, and fear of cancer progression, depending on whether advanced cancer patients were able to access novel therapies.

methodsAustralian adult advanced cancer patients who had exhausted all therapeutic options were recruited to undergo comprehensive genomic profiling (CGP) to determine whether a novel treatment was available. Questionnaires were administered prior to testing and within 2 weeks of receiving CGP results. Spiritual wellbeing was measured using the FACIT-Sp-12. Structural equation modeling was used to examine the predictive and mediating relationships among spiritual wellbeing at both time points, mediated by anxiety, depression and hope subscales at time 1 on the fear of cancer progression.

resultsBoth questionnaires were completed by 397 patients. A total of 238 (60%) patients had actionable CGP results. At baseline, the spiritual wellbeing constructs of meaning, peace and faith were identified as explanatory variables. At time 1, measures of spiritual wellbeing (meaning, peace and faith), and of hope, anxiety and depression, were identified as mediating variables for the outcome of fear of cancer progression. The test results were non-significant in the model.

conclusionsThe level of spiritual wellbeing in advanced cancer patients undergoing CGP was not impacted by test results but influenced a number of patient outcomes. Efforts to support patient spiritual wellbeing in such cohorts is recommended.

Indexed as

AnxietyDepressionNeoplasmsSpiritualityAdultAgedAustraliaDisease ProgressionFearFemaleGenetic TestingGenomicsHopeHumansMaleMiddle Agedanxietycancercomprehensive genomic testingdepressionFACIT‐sp‐12fear of cancer progressiongenomicshopespiritual wellbeing

Identifiers

PMID42026015
PMCPMC13106103

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.