ArticleMolecular metabolism2026
A distinct vagus-beta cell neural circuit senses glucose and modulates insulin secretion.
Article in Molecular metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveVagal sensory neurons (VSN) convey peripheral glycemic information to the brain, yet the specific pathways that continuously sense glucose fluctuations and regulate hormone secretion and feeding remain poorly defined. Here, we examined the anatomical and functional aspects of an integrated circuit originating in pancreatic β-cells, projecting through the nodose ganglion, and engaging the dorsal vagal complex to relay feedback to β-cells.
methodsWe performed monosynaptic viral fluorescent tracing, RNA sequencing, RNAscope, chemogenetics, optogenetics, neuronal silencing, automated glucose telemetry, feeding assays, neural activity measurements, glucose sensing, and intracellular calcium measurements using 2-photon microscopy.
resultsThe vagal transcriptome exhibited metabolic state- and diet-dependent regulation of pathways involved in glucose sensing, insulin secretion, and glucose homeostasis. Viral tracing identified abundant VSN innervating β-cells, including a subset expressing cocaine- and amphetamine-regulated transcript (VSN
conclusionsWe identified a vagal sensory neuron-β-cell circuit and showed that VSN
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