ArticleActa neuropsychiatrica2026
The effects of alpha-pinene on anxiety behaviours and TLR4/MYD88/NF-kB pathway in the hippocampus in the reserpine-induced anxiety model in rats.
Article in Acta neuropsychiatrica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveAnxiety disorders are prevalent neuropsychiatric conditions associated with neuroinflammation and altered cytokine signalling in the hippocampus. This study aimed to evaluate the anxiolytic-like effects of alpha-pinene and its potential modulation of hippocampal neuroinflammatory pathways in a reserpine-induced anxiety model.
methodsAdult male Wistar rats were randomly assigned to four groups: control (vehicle), reserpine (0.5 mg/kg, i.p.), and reserpine co-treated with alpha-pinene at 50 or 100 mg/kg. Treatments were administered intraperitoneally for 10 consecutive days. Behavioural assays – including the Open Field Test, Elevated Plus Maze, and Light/Dark Box Test – assessed locomotor activity and anxiety-like behaviours. Following testing, hippocampal tissues were collected for molecular analyses, including real-time PCR for TLR4, MyD88, and NF-κB expression, and ELISA quantification of IL-1β and IL-6 levels.
resultsReserpine induced robust anxiety-like behaviours, accompanied by significant upregulation of TLR4, MyD88, and NF-κB expression and increased hippocampal IL-1β and IL-6. Alpha-pinene treatment at both doses significantly attenuated anxiety-like behaviours and reduced neuroinflammatory markers, suggesting involvement of the TLR4/MyD88/NF-κB pathway.
conclusionAlpha-pinene exhibits anxiolytic-like effects in reserpine-treated rats, potentially via suppression of hippocampal neuroinflammation, supporting further investigation into its therapeutic potential for anxiety disorders.
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