Evidence map›Paper›PMID 42025581›Full record

ArticleHead & neck2026

Understanding the Symptom Burden of Complex Skull Base Tumors From the Patient's Perspective.

Shirley Y Su, Matheus Sewastjanow-Silva, Jack Phan, Marc-Elie Nader, Shaan M Raza, Franco DeMonte, Paul W Gidley, Ehab Y Hanna, Loretta A Williams

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Head & neck, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shirley Y SuDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.ORCID https://orcid.org/0000-0002-3903-8204
Matheus Sewastjanow-SilvaDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Jack PhanDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Marc-Elie NaderDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Shaan M RazaDepartment of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Franco DeMonteDepartment of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Paul W GidleyDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.ORCID https://orcid.org/0000-0003-3706-8781
Ehab Y HannaDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Loretta A WilliamsDepartment of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Funding

Duncan Family Institute for Cancer Prevention and Risk AssessmentUniversity Cancer Foundation, The University of Texas MD Anderson Cancer Center
6 · The paper itself

Abstract

backgroundSymptom burden of skull base tumor (SBT) patients, especially those undergoing multimodality treatment, is poorly understood. We aim to understand symptom burden in this patient group using the core module the MD Anderson Symptom Inventory (MDASI).

methodsTwenty-nine patients with benign and malignant SBT underwent qualitative interviews to capture symptoms at diagnosis, during, and after treatment. An expert panel of 47 members (patients, caregivers, and providers) rated identified symptoms for relevance.

resultsFifty-six individual symptoms were identified. Twenty-four symptoms met criteria for inclusion; 10 were already present in the MDASI core. Fourteen new SBT-specific symptoms were selected, adding to 13 core MDASI symptoms and 6 interference items to form the provisional MDASI-Skull Base.

conclusionsSBT patients experience wide ranging symptoms. A core cluster of symptoms is frequently reported across multiple SBT anatomical subsites. Further evaluation of the provisional MDASI-SB through psychometric testing in a larger group of patients is needed.

Indexed as

Skull Base NeoplasmsSymptom BurdenAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedQuality of Lifepatient‐reported outcomesinonasal cancerskull basesymptom burdensymptom interference

Identifiers

PMID42025581
PMCPMC13595466

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.