SynthesisPediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology2026
Skin barrier-related genes in childhood atopic dermatitis, asthma, and allergy: A systematic review and meta-analysis.
Synthesis in Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Skin barrier-related genes in childhood atopic dermatitis, asthma, and allergy: A systematic review and meta-analysis.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atopic dermatitis (AD), asthma, food allergy, and respiratory allergy are common childhood conditions with significant disease burden. Current understanding implicates the skin-barrier and the dual-allergen hypotheses in the pathophysiology of these allergic conditions. This systematic review and meta-analysis aimed to investigate the role of genes associated with primary skin barrier dysfunction in childhood atopic conditions. We conducted a comprehensive search across Embase, MEDLINE, Emcare, CINAHL, and Cochrane Central databases, yielding 6018 abstracts and 941 full-text articles, of which 60 met the inclusion criteria. Quality assessment was performed using the Q-GENIE tool. The full protocol is available on the PROSPERO database (registration ID CRD42022355771). Our analysis confirms a role for the filaggrin (FLG) gene, with meta-analysis revealing associations between FLG loss-of-function (LOF) mutations and AD (OR 2.426, 95% CI 1.890-3.114) in cohort studies and (OR 4.44, 95% CI 2.42-8.12) in case-control studies, asthma (OR 1.90, 95% CI 1.33-2.71), and food allergy (OR 1.79, 95% CI 1.11-2.88) in cohort studies. No statistically significant associations were found between FLG mutations and food allergy in case-control studies, or respiratory allergies. Included studies with insufficient clinical homogeneity for meta-analysis were presented as narrative synthesis, with studies looking at genetic associations with FLG (n = 28), FLG-2 (n = 1) and IL-18 (n = 1). The findings underscore the critical role of FLG mutations in childhood allergic conditions, particularly AD and asthma. However, we did not identify quantitative evidence for a clinically significant role for other skin barrier-related genes in relation to childhood allergy. Limitations include the exclusion of non-English-language studies and potential omissions of genes not represented in the Gene Ontology Skin Barrier database. Future research could explore personalized medicine according to FLG genotype to mitigate the effects of environmental exposures and reduce the burden of atopic diseases in children.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.