ArticleKorean journal of ophthalmology : KJO2026
Clinical Outcomes of Trabecular Micro-Bypass Stent in Patients with Moderate-to-Severe Open-Angle Glaucoma.
Article in Korean journal of ophthalmology : KJO, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo evaluate 1-year clinical outcomes and response markers after implantation of a trabecular micro-bypass stent (iStent inject W) in patients with moderate-to-severe open-angle glaucoma (OAG).
methodsThis retrospective cohort study included 22 eyes of 22 patients with moderate-to-severe OAG who underwent standalone iStent inject W implantation (n = 4) or combined phacoemulsification with iStent inject W (n = 18). Qualified surgical success was defined as intraocular pressure (IOP) ≤15 mmHg with glaucoma medications and either ≥25% IOP reduction or final IOP ≤12 mmHg if baseline IOP was ≤15 mmHg. Kaplan-Meier analysis was used for cumulative probability of success; Cox proportional hazards regression analysis was used to identify response markers of surgical failure.
resultsBased on 19 eyes after censoring three eyes requiring additional surgery, IOP reduced from 22.09 ± 5.62 mmHg preoperatively to 12.34 ± 2.43 mmHg at 1 year (p < 0.001). Cumulative qualified success rates were 90.9% at 6 months and 72.7% at 12 months. No statistically significant changes were observed in the number of IOP-lowering medications. Higher postoperative IOP at 1 week and 1 month were independently associated with a higher surgical failure rate, with hazard ratios of 1.112 at 1 week (p = 0.002) and 1.324 at 1 month (p = 0.017). Transient hyphema occurred in seven eyes and resolved within 1 week; iStent iris plugging occurred in two eyes; and three eyes required subsequent trabeculectomy.
conclusionsiStent inject W appeared to provide meaningful IOP reduction and may serve as an intermediate option in patients with moderate-to-severe OAG. Early higher postoperative IOP may be an early response marker associated with surgical failure.
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