Evidence map›Paper›PMID 42025175›Full record

ArticleCurrent biology : CB2026

Evolutionary history of Jamestown Canyon virus reveals complex multi-vector ecology.

Ellie Bourgikos, Simon Dellicour, Philippe Lemey, Nicole M Feriancek, Angela B Bransfield, Mallery I Breban, Michael J Misencik, Tanya A Petruff, John J Shepard, Theodore G Andreadis and 19 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current biology : CB, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

29 authors.

Ellie BourgikosDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA. Electronic address: ellie.bourgikos@yale.edu.
Simon DellicourSpatial Epidemiology Laboratory (SpELL), Université Libre de Bruxelles, Brussels 1050, Belgium; Department of Microbiology, Immunology, and Transplantation, Rega Institute, KU Leuven, Leuven 3000, Belgium.
Philippe LemeyDepartment of Microbiology, Immunology, and Transplantation, Rega Institute, KU Leuven, Leuven 3000, Belgium.
Nicole M FeriancekDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA.
Angela B BransfieldCenter for Vector Biology and Zoonotic Diseases, Department of Entomology, The Connecticut Agricultural Experiment Station, New Haven, CT 06511, USA.
Mallery I BrebanDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA.
Michael J MisencikCenter for Vector Biology and Zoonotic Diseases, Department of Entomology, The Connecticut Agricultural Experiment Station, New Haven, CT 06511, USA.
Tanya A PetruffCenter for Vector Biology and Zoonotic Diseases, Department of Entomology, The Connecticut Agricultural Experiment Station, New Haven, CT 06511, USA.
John J ShepardCenter for Vector Biology and Zoonotic Diseases, Department of Entomology, The Connecticut Agricultural Experiment Station, New Haven, CT 06511, USA.
Theodore G AndreadisCenter for Vector Biology and Zoonotic Diseases, Department of Entomology, The Connecticut Agricultural Experiment Station, New Haven, CT 06511, USA.
John F AndersonCenter for Vector Biology and Zoonotic Diseases, Department of Entomology, The Connecticut Agricultural Experiment Station, New Haven, CT 06511, USA.
Kiet A NgoThe Arbovirus Laboratory, New York State Department of Health, Wadsworth Center, Slingerlands, NY 12159, USA.
Joseph G MaffeiThe Arbovirus Laboratory, New York State Department of Health, Wadsworth Center, Slingerlands, NY 12159, USA.
Alan P DupuisThe Arbovirus Laboratory, New York State Department of Health, Wadsworth Center, Slingerlands, NY 12159, USA.
Stephen M RichNew England Center of Excellence in Vector-Borne Diseases, University of Massachusetts, Amherst, Amherst, MA 01003, USA; Department of Microbiology, College of Natural Sciences, University of Massachusetts, Amherst, Amherst, MA 01003, USA.
Guang XuNew England Center of Excellence in Vector-Borne Diseases, University of Massachusetts, Amherst, Amherst, MA 01003, USA; Department of Microbiology, College of Natural Sciences, University of Massachusetts, Amherst, Amherst, MA 01003, USA.
Gabrielle SakolskyCape Cod Mosquito Control, Yarmouthport, MA 02675, USA.
Keith J PriceDivision of Vector Management, Pennsylvania Department of Environmental Protection, Harrisburg, PA 17101, USA.
Madeline L MetzgerDivision of Vector Management, Pennsylvania Department of Environmental Protection, Harrisburg, PA 17101, USA.
Marc A SuchardDepartment of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Biomathematics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Rafael LopesDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA; Public Health Modeling Unit, Yale School of Public Health, New Haven, CT 06510, USA.
Fabiana GámbaroSpatial Epidemiology Laboratory (SpELL), Université Libre de Bruxelles, Brussels 1050, Belgium.
Colin J CarlsonDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA; Public Health Modeling Unit, Yale School of Public Health, New Haven, CT 06510, USA.
Guy BaeleDepartment of Microbiology, Immunology, and Transplantation, Rega Institute, KU Leuven, Leuven 3000, Belgium.
Alexander T CiotaThe Arbovirus Laboratory, New York State Department of Health, Wadsworth Center, Slingerlands, NY 12159, USA; Department of Biomedical Sciences, State University of New York, Albany School of Public Health, Albany, NY 12237, USA.
Chantal B F VogelsDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA.
Verity HillDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA; Department of Microbiology, Immunology, and Transplantation, Rega Institute, KU Leuven, Leuven 3000, Belgium.
Philip M ArmstrongDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA; Center for Vector Biology and Zoonotic Diseases, Department of Entomology, The Connecticut Agricultural Experiment Station, New Haven, CT 06511, USA.
Nathan D GrubaughDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA; Public Health Modeling Unit, Yale School of Public Health, New Haven, CT 06510, USA; Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT 06510, USA. Electronic address: nathan.grubaugh@yale.edu.

Funding

Enhancing dengue virus genomic surveillance to uncover circulating genetic diversityDP2AI176740 · NIAID · YALE UNIVERSITY · PI GRUBAUGH, NATHAN DALE · 2022 to 2025
$2.5M
High Performance Computing Instrumentation for the Yale Center for Genome AnalysisS10OD030363 · OD · YALE UNIVERSITY · PI MANE, SHRIKANT M · 2022 to 2022
$1.2M
NIAID NIH HHS DP2 AI176740NIH HHS S10 OD030363
6 · The paper itself

Abstract

Jamestown Canyon virus (JCV) is a historically understudied mosquito-borne virus of increasing concern in North America. We generated 658 whole-genome JCV sequences from northeast United States, including 84% (500/597) of all JCV-positive mosquitoes detected in Connecticut from 1997 to 2022. Then, we applied phylodynamic methods to demonstrate how mosquito phenology structures the maintenance and evolution of JCV. Our phylogenetic analyses estimate that JCV was introduced in the Northeast by at least the early 1700s, and the primary introductions of lineages A and B into Connecticut occurred during the mid-1800s to mid-1900s. Further, we estimate that JCV evolves at a rate of ∼3 × 10

Indexed as

AedesBiological EvolutionCulicidaeEncephalitis Virus, CaliforniaEvolution, MolecularMosquito VectorsAnimalsConnecticutGenome, ViralPhylogenyarbovirusdisease ecologyJamestown Canyon virusmosquitoesphylogeneticssequencingvirus evolution

Identifiers

PMID42025175
PMCPMC13613370

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.