ArticleCell genomics2026
Regulatory network topology and the genetic architecture of gene expression.
Article in Cell genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Identification of miR-21-5p and miR-21-3p regulated hub genes and drug repurposing targets in cervical cancer: an integrative computational analysis.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Article
- Leveraging low-cost short-read sequencing: revolutionizing complex trait genetics.Molecular biology and evolution · 2026Article
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4 authors.
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Abstract
Most genetic variance in gene expression is due to trans-acting expression quantitative trait loci (eQTLs) spread across the genome. However, these loci are generally hard to map due to limited discovery power. Here, we simulate how local properties of expression regulation and global properties of regulatory networks alter the genome-wide proportions of cis- and trans-heritability. We find that network motifs and modular groups can reduce or enhance the effects of trans-eQTLs and that hub regulators shorten paths across the network and act as key sources of trans-acting variance. Critically, networks with all these features best recapitulate the observed distribution of cis- and trans-heritability. Taken together, our results suggest that the genome-wide genetic architecture of gene expression involves fewer regulators for each gene but implicates the same regulators more often across genes (i.e., is less polygenic and more pleiotropic) than previously anticipated.
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