ReviewInternational dental journal2026
Notch Signalling Pathway in the Pathogenesis of Periodontitis: Research Progress.
Review in International dental journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThis review examines the pivotal role of the Notch signalling pathway in the pathogenesis of periodontitis. We focus on its impact on the host inflammatory response, immune regulation, and alveolar bone homeostasis. By delineating how periodontal pathogens activate this pathway to exacerbate tissue damage, we also explore its potential as a therapeutic target.
methodsThis article synthesises and critically examines recent advances in research on the Notch signalling pathway in the context of periodontitis. By comprehensively reviewing and evaluating current literature, the methods include analysing mechanistic insights, experimental findings, and clinical evidence related to Notch signalling in periodontal pathogenesis.
resultsThe review highlights that the Notch signalling pathway significantly influences the pathogenesis of periodontitis, impacting key disease processes such as inflammation, immune response, and tissue regeneration. It summarises evidence demonstrating the pathway's involvement in disease progression and its potential as a therapeutic target, while also identifying existing challenges and gaps in current knowledge.
conclusionThis review underscores the critical role of Notch signalling in periodontitis and contributes to a deeper understanding of the molecular mechanisms driving the disease. It encourages the development of novel therapeutic strategies and emphasises the need for further research to address unresolved questions and translate findings into clinical applications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.