ArticleInternational dental journal2026
The JNJ0966 Significantly Reduces the Elevated Serum MMP-9 and Blood Pressure Observed in SHRs With Periodontitis.
Article in International dental journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
INTRODUCTION AND
aimsPeriodontitis can cause increases in blood pressure and is a risk factor for poor control of hypertension. Previous studies have found that serum matrix metalloproteinase-9 (MMP-9) is significantly increased in patients with hypertension combined with periodontitis, but it has not been demonstrated whether elevated MMP-9 is related to elevated blood pressure. In this study, we examined whether serum MMP-9 and blood pressure are concomitantly elevated in spontaneously hypertensive rats (SHRs) with periodontitis and explored the potential mechanism.
methodsThirty-six 12-week-old male SHRs were randomly divided into an experimental periodontitis group (SHR-L, n = 18) and a nonperiodontitis group (SHR-C, n = 18). Four weeks later, the SHR-C and SHR-L groups were each randomly divided into 3 subgroups and received JNJ0966 (a specific inhibitor of MMP-9) by gavage once per day for 7 days at doses of 0, 10 and 30 mg/kg (n = 6 in each subgroup). Then, the noninvasive caudal artery pressure and serum concentrations of MMP-9, TIMP-1 and Ang II were measured.
resultsAfter 5 weeks of modelling, the MMP-9 levels and the MMP-9/TIMP-1 ratio, the Ang II concentration and the blood pressure measurement were all significantly higher in the SHR-L-0 group than in the SHR-C-0 group (P < 0.05). After intervention with JNJ0966, blood pressure and serum MMP-9 and Ang II levels were significantly lower in the SHR-C-30 group than in the SHR-C-0 group. Compared with those in the SHR-L-0 group, blood pressure, serum MMP-9 levels, the MMP-9/TIMP-1 ratio and Ang II levels were significantly lower in the SHR-L-10 and SHR-L-30 groups (P < 0.05).
conclusionSystemic application of JNJ0966 can significantly reduce the elevated serum MMP-9 and blood pressure observed in SHR with periodontitis. CLINICAL RELEVANCE: This indicates that MMP-9 may be 1 mechanism underlying the increased blood pressure in patients with periodontitis.
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