Evidence map›Paper›PMID 42025057›Full record

ArticleRedox biology2026

Macrophage MERTK restrains GRAMD1A-driven mitochondrial oxysterol trafficking to limit colitis.

Juanhan Liu, Peizhao Liu, Yangguang Li, Tao Zheng, Cunxia Wu, Wenbin Gong, Ze Li, Guiwen Qu, Xuanheng Li, Yiyu Yang and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Juanhan LiuResearch Institute of General Surgery, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210002, PR China; Department of General Surgery, BenQ Medical Center, Nanjing Medical University, Nanjing, 210002, PR China.
Peizhao LiuResearch Institute of General Surgery, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210002, PR China; Department of General Surgery, BenQ Medical Center, Nanjing Medical University, Nanjing, 210002, PR China.
Yangguang LiResearch Institute of General Surgery, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210002, PR China; Department of General Surgery, BenQ Medical Center, Nanjing Medical University, Nanjing, 210002, PR China.
Tao ZhengDepartment of Abdominal Acute Care Surgery, General Surgery Center, Shanghai General Hospital, Shanghai Jiao Tong, University School of Medicine, Shanghai, PR China.
Cunxia WuResearch Institute of General Surgery, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210002, PR China.
Wenbin GongDepartment of Gastroenterology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, PR China.
Ze LiResearch Institute of General Surgery, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210002, PR China.
Guiwen QuSchool of Medicine, Southeast University, Nanjing, 211189, PR China.
Xuanheng LiResearch Institute of General Surgery, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210002, PR China.
Yiyu YangDepartment of Abdominal Acute Care Surgery, General Surgery Center, Shanghai General Hospital, Shanghai Jiao Tong, University School of Medicine, Shanghai, PR China.
Qianwen LiSchool of Medicine, Southeast University, Nanjing, 211189, PR China.
Fansen LinDepartment of Intensive Care Unit, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, 350005, PR China.
Jinyao LiuDepartment of General Surgery, BenQ Medical Center, Nanjing Medical University, Nanjing, 210002, PR China.
Zexing LinDepartment of General Surgery, BenQ Medical Center, Nanjing Medical University, Nanjing, 210002, PR China.
Yun ZhaoDepartment of General Surgery, BenQ Medical Center, Nanjing Medical University, Nanjing, 210002, PR China. Electronic address: zhaoyun@njmu.edu.cn.
Jianan RenResearch Institute of General Surgery, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210002, PR China. Electronic address: jiananr@nju.edu.cn.
Xiuwen WuResearch Institute of General Surgery, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210002, PR China. Electronic address: wuxiuwen@nju.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Impaired macrophage efferocytosis drives chronic inflammation, yet the underlying immunometabolic mechanisms remain poorly defined. In this study, we identify that impaired macrophage efferocytosis triggers excessive mitochondrial oxysterol accumulation, which drives mitochondrial ROS-associated inflammation in Crohn's disease (CD). We report an inverse correlation between CD activity and the abundance of MERTK

Indexed as

c-Mer Tyrosine KinaseColitisMacrophagesMitochondriaOxysterolsAnimalsCholesterolEfferocytosisEndoplasmic ReticulumHumansMiceReactive Oxygen SpeciesCholesterolc-Mer Tyrosine KinaseMertk protein, mouseOxysterolsReactive Oxygen SpeciesCrohn's diseaseMERTKMitochondrial oxidative phosphorylationOxysterolsROS

Identifiers

PMID42025057
PMCPMC13123613

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.