Evidence map›Paper›PMID 42025005›Full record

ArticlePoultry science2026

Houttuynia cordata extract protects against Salmonella infection by targeting type III secretion system 1.

Tao Wang, Siyu Cai, Jingjing Zhang, Jianfeng Wang, Xuming Deng, Kelong Ma, Hongtao Liu, Jiazhang Qiu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Poultry science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Animals : an open access journal from MDPI · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tao WangState Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases & Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine & Jilin University, Changchun 130062, China.
Siyu CaiState Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases & Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine & Jilin University, Changchun 130062, China.
Jingjing ZhangState Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases & Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine & Jilin University, Changchun 130062, China.
Jianfeng WangState Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases & Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine & Jilin University, Changchun 130062, China.
Xuming DengState Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases & Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine & Jilin University, Changchun 130062, China.
Kelong MaState Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases & Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine & Jilin University, Changchun 130062, China.
Hongtao LiuState Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases & Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine & Jilin University, Changchun 130062, China.
Jiazhang QiuState Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases & Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine & Jilin University, Changchun 130062, China. Electronic address: qiujz@jlu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Salmonella is a major zoonotic pathogen and a leading cause of foodborne illness worldwide, posing serious threats to public health and livestock production. The rapid emergence of multidrug-resistant strains underscores the urgent need for alternative anti-infective strategies. Antivirulence therapies targeting pathogen virulence factors (e.g., the type III secretion system 1, T3SS-1) have gained increasing attention because they mitigate infection and minimize resistance development. Here, we systematically evaluated the protective efficacy of Houttuynia cordata extract (HCE) in both murine and economically relevant chick infection models of Salmonella Typhimurium and Salmonella Pullorum. HCE significantly improved host pathology, alleviated intestinal barrier damage, reduced bacterial burden in target organs and modulated inflammatory responses. Mechanistically, HCE downregulated HilA, the central transcriptional regulator of T3SS-1, thereby suppressing effector protein secretion and bacterial invasion. These findings provide robust in vivo evidence supporting HCE as a low-cost, natural antivirulence candidate for the prevention and control of Salmonella infections in the poultry farming industry.

Indexed as

Anti-Bacterial AgentsDrugs, Chinese HerbalHouttuyniaPoultry DiseasesProtective AgentsSalmonellaSalmonella Infections, AnimalSalmonella typhimuriumType III Secretion SystemsAnimalsChickensMiceAnti-Bacterial AgentsDrugs, Chinese HerbalHouttuynia cordata extractProtective AgentsType III Secretion SystemsAntivirulenceHilAHouttuynia cordata extractSalmonellaType III secretion system 1

Identifiers

PMID42025005
PMCPMC13125183

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.