Evidence map›Paper›PMID 42024909›Full record

ArticleThe Indian journal of medical research2026

Epidemiology of vaso-occlusive crisis among sickle cell disease patients in India: A community-based multi-centric study.

Shaily B Surti, Shubhangi Patel, Yogita Sharma, Deepa Bhat, Parikipandla Sridevi, Jatin Sarmah, Madhusmita Bal, Manoranjan Ranjit, Rabindra Kumar Jena, Bontha V Babu

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Indian journal of medical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Shaily B SurtiDepartment of Community Medicine, Parul Institute of Medical Sciences and Research, Parul University, Vadodara, Gujarat, India.
Shubhangi PatelDepartment of Community Medicine, Parul Institute of Medical Sciences and Research, Parul University, Vadodara, Gujarat, India.
Yogita SharmaDepartment of Community Medicine, Parul Institute of Medical Sciences and Research, Parul University, Vadodara, Gujarat, India.
Deepa BhatDepartment of Community Medicine, Parul Institute of Medical Sciences and Research, Parul University, Vadodara, Gujarat, India.
Parikipandla SrideviDepartment of Community Medicine, Parul Institute of Medical Sciences and Research, Parul University, Vadodara, Gujarat, India.
Jatin SarmahDepartment of Community Medicine, Parul Institute of Medical Sciences and Research, Parul University, Vadodara, Gujarat, India.
Madhusmita BalDepartment of Community Medicine, Parul Institute of Medical Sciences and Research, Parul University, Vadodara, Gujarat, India.
Manoranjan RanjitDepartment of Community Medicine, Parul Institute of Medical Sciences and Research, Parul University, Vadodara, Gujarat, India.
Rabindra Kumar JenaDepartment of Clinical Hematology, SCB Medical College and Hospital, Cuttack, Odisha, India.
Bontha V BabuDivision of Socio-Behavioural, Health Systems & Implementation Research, Indian Council of Medical Research, New Delhi, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and objectives Morbidity burden of sickle cell disease (SCD) in India has been underestimated till now due to a lack of nationwide data on the prevalence of clinical outcomes, including the most prevalent clinical manifestations like vaso-occlusive crises (VOCs). This multi-centric study reports the epidemiological characteristics of VOCs among SCD patients in India. Methods This is a prospective, community-based, multi-centre cohort study with fortnightly home visits conducted over 12 months in five SCD-endemic districts of India. A cohort of 252 patients was followed up, and data regarding any illness related to SCD and its management in the previous fortnight were collected using a structured questionnaire. Results Out of the total 252 SCD patients followed up, 223 (88.5%) patients reported 2118 crises in a year [8404 episodes per 1000 patients-year; 95% confidence interval (CI): 8040-8760]. Pain anywhere in the body was the most prevalent symptom [97.3% (n=217) of the participants, with 7 (3-13) median (IQR) episodes per patient in a year]. Among total crisis episodes, 48.7% (n=1031) of the episodes were treated at a health facility. Interpretation and conclusions A higher number of crisis episodes reported among the majority of the patients demystifies the notion that SCD is milder and less severe in India. The lower utilization of healthcare resources among SCD patients raises a serious concern.

Indexed as

Anemia, Sickle CellVaso-Occlusive CrisesAdolescentAdultChildFemaleHumansIndiaMalePainPrevalenceProspective StudiesSurveys and QuestionnairesYoung AdultAcute illnessEpidemiologySickle cell diseaseTribal healthVaso-occlusive crisis

Identifiers

PMID42024909
PMCPMC13126539

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LicenceCC BY-NC-SA
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.