ArticleScience (New York, N.Y.)2026
Mechanical load inhibits cancer growth in mouse and human hearts.
Article in Science (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Cardiac unloading models for myocardial reverse remodeling.Basic research in cardiology · 2026Review
- Mechanical load as an endogenous tumor suppressor: Nesprin-2-mediated mechanotransduction reshapes the cancer epigenome.Signal transduction and targeted therapy · 2026Article
- The beating heart as a tumour-suppressive niche.Nature reviews. Cardiology · 2026Article
- In vitro multi-organ invasion model for exploring cardiac resistance to cancer metastasis.Nature communications · 2026Article
- Cyclic stretch inhibits cell invasion in 3D scaffolds.bioRxiv : the preprint server for biology · 2026Article
- Mechanical forces of beating heart suppress cancer growth.Mechanobiology in medicine · 2026Article
- The heart puts pressure on cancer growth.Science (New York, N.Y.) · 2026Article
- The role ofFrontiers in immunology · 2026Article
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Authors and funding
35 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The heart rarely develops cancer, and, at the same time, it lacks regenerative capacity, as cardiomyocytes stop proliferating after birth. This suggests that mechanisms limiting cardiac regeneration may also protect against cancer. In this work, we investigated the role of mechanical load and used in vivo cancer models and ex vivo engineered heart tissues to show that mechanical load reduces cancer cell proliferation in the myocardium. Spatial transcriptomics of human cardiac metastases revealed decreased histone methylation and chromatin compaction. These changes affect chromatin accessibility at proliferation-related loci, with Nesprin-2 identified as a key mechanosensor. Our results uncover how mechanical forces protect the heart from cancer and suggest potential strategies for cancer therapy based on mechanical stimulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.