Observational studyJournal of surgical oncology2026
Impact of Surgical Margins in Chest Wall Chondrosarcomas: A CanSaRCC Study.
Observational study in Journal of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
22 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChest wall chondrosarcoma is the most common primary malignant bone tumor of the thoracic cage. Owing to its resistance to chemotherapy and radiotherapy, complete surgical excision with negative margins remains the cornerstone of treatment. However, the optimal margin width for local control and survival remains uncertain.
methodsData from nine Canadian sarcoma centres participating in the CanSaRCC registry were retrospectively reviewed. Patients aged ≥ 18 years with pathologically confirmed primary chest wall chondrosarcoma (2000-2024) who underwent curative-intent resection were included. Margins were defined as the minimum measured distance from tumor to resection margin, irrespective of tissue type and categorized as positive, < 4 mm, or ≥ 4 mm. Overall survival (OS), disease-free survival (DFS), and local recurrence free survival (LRFS) were analysed using Kaplan-Meier and multivariable Cox regression.
resultsAmong 147 patients (median age 54 years (range; 21-85), 16% had positive margins, 52% < 4 mm, and 24% ≥ 4 mm. At 5 years, OS and DFS were 77% (±4.8%) and 68% (±5.2%), respectively, for the entire cohort. Independent predictors of worse overall survival included tumor size ≥ 10 cm (HR 3.23, p = 0.021) and grade 3 tumors (HR 12.40, p < 0.001) but not margin size (margin ≥ 4 mm; HR 0.70, p = 0.512). Margins ≥ 4 mm significantly reduced local recurrence (HR 0.12, p = 0.023).
conclusionsIn primary chest wall chondrosarcoma, tumor biology rather than surgical margin width drives systemic outcomes. Margins ≥ 4 mm improve local control, supporting balanced resections that preserve function while maintaining oncologic safety.
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