ArticleStereotactic and functional neurosurgery2026
Evaluating Cognitive and Affective Changes after Responsive Neurostimulation of the Centromedian Thalamus.
Article in Stereotactic and functional neurosurgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionResponsive electrical stimulation of the centromedian nucleus of the thalamus (CMN) is an emerging therapy for reducing seizures in individuals with multifocal or generalized drug-resistant epilepsy (DRE). Prior studies have reported significant neuropsychiatric side effects associated with thalamic stimulation, particularly in the anterior nucleus of the thalamus. Despite its growing popularity, little is known about the effects of CMN stimulation on neurocognitive and mood outcomes. To address this knowledge gap, we performed a retrospective analysis of patients who underwent responsive neurostimulation (RNS) of the CMN at our institution.
methodsWe identified 8 patients with multifocal or unresectable focal DRE who participated in a comprehensive evaluation before and ∼12 months after surgery to implant an RNS device. Neuropsychological testing spanned multiple functional domains (i.e., attention and working memory, learning, retrieval, phonemic fluency, semantic fluency, motor dexterity, mood, and anxiety), and 9 distinct functional metrics were analyzed.
resultsIn this small retrospective cohort, closed-loop stimulation of the CMN was associated with modest improvements in verbal learning and retrieval and a slight decline in phonemic verbal fluency. Although there was no robust group-level effect on mood, the proportion of patients with clinically significant depression decreased from 43% before stimulation to 0% at last follow-up and from 71% to 57% for clinically significant anxiety. Our analyses did not identify changes in attention and working memory, semantic fluency, or motor dexterity.
conclusionOur results suggest that closed-loop CMN stimulation was not associated with major adverse cognitive or affective changes over 12 months.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.