Evidence map›Paper›PMID 42024569›Full record

ArticleJACC. Case reports2026

Baroreflex Activation Therapy in HFrEF Patients: Anti-Inflammatory Effects and Autonomic Restoration.

Alexandra Bekiaridou, Kristie Coleman, Nhan Nguyen, Seth Wilks, Alfio Carroccio, Haisam Ismail, Marcin Kowalski, Miguel Alvarez Villela, Sirish Vullaganti, Theodoros Zanos and 2 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alexandra BekiaridouNorthwell Health, New Hyde Park, New York, USA; Elmezzi Graduate School of Molecular Medicine, Northwell Health, Manhasset, New York, USA.
Kristie ColemanNorthwell Health, New Hyde Park, New York, USA; Northwell Cardiovascular Institute, New York, New York, USA. Electronic address: kcoleman1@northwell.edu.
Nhan NguyenNorthwell Health, New Hyde Park, New York, USA; Northwell Cardiovascular Institute, New York, New York, USA.
Seth WilksCVRx Inc, Minneapolis, Minnesota, USA.
Alfio CarroccioNorthwell Health, New Hyde Park, New York, USA; Northwell Cardiovascular Institute, New York, New York, USA.
Haisam IsmailNorthwell Health, New Hyde Park, New York, USA; Northwell Cardiovascular Institute, New York, New York, USA.
Marcin KowalskiNorthwell Health, New Hyde Park, New York, USA; Northwell Cardiovascular Institute, New York, New York, USA.
Miguel Alvarez VillelaNorthwell Health, New Hyde Park, New York, USA; Northwell Cardiovascular Institute, New York, New York, USA.
Sirish VullagantiNorthwell Health, New Hyde Park, New York, USA; Northwell Cardiovascular Institute, New York, New York, USA.
Theodoros ZanosNorthwell Health, New Hyde Park, New York, USA; Elmezzi Graduate School of Molecular Medicine, Northwell Health, Manhasset, New York, USA.
Stavros ZanosNorthwell Health, New Hyde Park, New York, USA; Elmezzi Graduate School of Molecular Medicine, Northwell Health, Manhasset, New York, USA.
Stavros MountantonakisNorthwell Health, New Hyde Park, New York, USA; Northwell Cardiovascular Institute, New York, New York, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBaroreflex activation therapy (BAT) may ameliorate autonomic imbalance in patients after heart failure with reduced ejection fraction (HFrEF); however, its effects on systemic inflammation and autonomic indices remain unknown. CASE SUMMARY: Seven patients with advanced HFrEF underwent BAT implantation. Three cases are presented in detail, illustrating distinct response patterns: clinical improvement, robust parasympathetic restoration, and anti-inflammatory response. DISCUSSION: After BAT, patients demonstrated improvements in quality of life, heart rate variability (HRV), and inflammatory biomarkers (tumor necrosis factor-α, interferon-γ). These preliminary findings suggest that BAT may exert therapeutic benefits through both autonomic restoration and anti-inflammatory modulation. TAKE-HOME MESSAGES: An aggregate analysis of 7 patients with HFrEF who received BAT demonstrated favorable responses in inflammatory biomarkers, HRV, and clinical outcomes. BAT led to decrease in tumor necrosis factor-α and interferon-γ and autonomic balance restoration as measured by HRV. These findings support further investigation into the mechanisms of action of BAT.

Indexed as

baroreflex activation therapycytokinesheart failureheart rate variabilityinflammationneuromodulation

Identifiers

PMID42024569
PMCPMC13261858

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.