Evidence map›Paper›PMID 42024441›Full record

ArticleThe Journal of clinical investigation2026

T cell receptor signaling induces expression of lysine demethylase KDM6B to maintain Treg homeostasis.

Minghong He, Beisi Xu, Pria G Bose, Morgan J McCullough, Rani S Sellers, Xinying Zong, Wenjie Qi, Brianna L Banten, Miriya K Tune, Matthew P Zimmerman and 12 more

Abstract read
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In one paragraph

Article in The Journal of clinical investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Minghong HeDepartment of Immunology, and.
Beisi XuCenter for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Pria G BoseMarsico Lung Institute.
Morgan J McCulloughMarsico Lung Institute.
Rani S SellersDepartment of Pathology and Laboratory Medicine.
Xinying ZongDepartment of Immunology, and.
Wenjie QiCenter for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Brianna L BantenMarsico Lung Institute.
Miriya K TuneMarsico Lung Institute.
Matthew P ZimmermanDepartment of Cell Biology and Physiology, and.
Genevieve MullinsLineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA.
Brian C MillerDepartment of Microbiology and Immunology.
J Justin MilnerDepartment of Microbiology and Immunology.
Jason K WhitmireDepartment of Microbiology and Immunology.
Ageliki TsagaratouLineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA.
Karl B ShpargelDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Claire M DoerschukMarsico Lung Institute.
Yong-Dong WangDepartment of Cell and Molecular Biology, and.
Jacob A SteeleDepartment of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Shondra M Pruett-MillerDepartment of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Yongqiang FengDepartment of Immunology, and.
Jason R MockMarsico Lung Institute.

Funding

Robust immune tolerance conferred by Foxp3 transcriptional regulationR01AI153138 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI FENG, YONGQIANG · 2021 to 2025
$2.2M
Identify novel modulators of regulatory T cell function from the dynamic cis-proteomesR21AI163942 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI FENG, YONGQIANG · 2021 to 2022
$494k
NIAID NIH HHS R01 AI153138NIAID NIH HHS R21 AI163942
6 · The paper itself

Abstract

Tregs expressing forkhead box P3 (FOXP3) play crucial roles in maintaining immune tolerance and tissue integrity. EZH2, a histone H3 lysine 27 (H3K27) methyltransferase, is known as a key regulator of Treg identity and suppressive function upon activation. Here, we demonstrate that the H3K27 lysine demethylase KDM6B, which catalyzes the opposing reaction to EZH2, is also required for Treg identity and function after activation. Treg-specific deletion of Kdm6b impaired tissue Treg fate and function. KDM6B was upregulated after T cell antigen receptor signaling in Tregs and contributed to the regulation of Treg-associated gene expression through both direct and indirect mechanisms. A subset of Treg functional genes were direct targets of KDM6B and were co-occupied by FOXP3 at cis-regulatory regions, where KDM6B recruitment limited H3K27me3 accumulation. More broadly, KDM6B-dependent H3K27 demethylation facilitated Treg gene expression programs that supported tissue Treg homeostasis.

Indexed as

HomeostasisJumonji Domain-Containing Histone DemethylasesReceptors, Antigen, T-CellSignal TransductionT-Lymphocytes, RegulatoryAnimalsEnhancer of Zeste Homolog 2 ProteinForkhead Transcription FactorsHistonesHumansMiceMice, KnockoutEnhancer of Zeste Homolog 2 ProteinEzh2 protein, mouseForkhead Transcription FactorsFoxp3 protein, mouseHistonesJumonji Domain-Containing Histone DemethylasesKdm6b protein, mouseReceptors, Antigen, T-CellCellular immune responseEpigeneticsImmunologyPulmonologyTregs

Identifiers

PMID42024441
PMCPMC13318106

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.