Evidence map›Paper›PMID 42024254›Full record

ArticleInternational orthopaedics2026

Impact of timing of menopause on musculoskeletal disorders and associated pain in community-dwelling women: the Yakumo study.

Shinya Tanaka, Yusuke Osawa, Hiroto Funahashi, Hiroaki Ido, Yasuhiko Takegami, Hiroaki Nakashima, Shinya Ishizuka, Taisuke Seki, Yukiharu Hasegawa, Shiro Imagama

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Article in International orthopaedics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Shinya TanakaDepartment of Orthopedic Surgery, Graduate School of Medicine, Nagoya University, Nagoya, Japan. shinn.0118@gmail.com.
Yusuke OsawaDepartment of Orthopedic Surgery, Graduate School of Medicine, Nagoya University, Nagoya, Japan. ysk0568@yahoo.co.jp.
Hiroto FunahashiDepartment of Orthopedic Surgery, Graduate School of Medicine, Nagoya University, Nagoya, Japan.
Hiroaki IdoDepartment of Orthopedic Surgery, Graduate School of Medicine, Nagoya University, Nagoya, Japan.
Yasuhiko TakegamiBiomedical Imaging and Informatics, Department of Integrated Health Sciences, Nagoya University, Nagoya, Japan.
Hiroaki NakashimaDepartment of Orthopedic Surgery, Graduate School of Medicine, Nagoya University, Nagoya, Japan.
Shinya IshizukaDepartment of Orthopedic Surgery, Graduate School of Medicine, Nagoya University, Nagoya, Japan.
Taisuke SekiDepartment of Orthopaedic Surgery, Aichi Medical University Medical Center, Okazaki, Japan.
Yukiharu HasegawaDepartment of Occupational Therapy, Faculty of Rehabilitation, Aichi Medical College, Kiyosu, Japan.
Shiro ImagamaDepartment of Orthopedic Surgery, Graduate School of Medicine, Nagoya University, Nagoya, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPremature ovarian insufficiency (POI) and early menopause (EM) lead to prolonged estrogen deficiency, which can affect musculoskeletal disorders (MSDs) and pain, including neuropathic pain. This study investigated the impact of POI/EM on MSDs, pain, and physical function in community-dwelling women.

methodsWe conducted a cross-sectional study using data from 172 postmenopausal women who participated in a community-based health checkup in Yakumo town, Japan. Participants were categorized by age at menopause: control (45-50 years, n = 118), POI (< 40 years, n = 19), and EM (40-44 years, n = 35). We evaluated MSDs (knee osteoarthritis, spinal alignment, and osteoporosis), pain (Visual Analogue Scale for low back, lower limb, and knee pain; and painDETECT scores), and physical function (muscle strength, walking ability, locomotive syndrome). Locomotive syndrome was evaluated using the stand-up test, two-step test, and the 25-question Geriatric Locomotive Function Scale (GLFS-25).

resultsThe POI group exhibited a significantly higher prevalence of knee osteoarthritis and severe knee pain compared to the control and EM groups. The prevalence of neuropathic pain was also significantly higher in the POI group. Regarding physical function, no significant differences were observed in muscle strength or walking ability among the groups. However, the POI group had significantly higher scores on the GLFS-25 pain subscale and total score, indicating worse locomotive function.

conclusionsWomen with POI had a higher prevalence of knee osteoarthritis, knee pain, and neuropathic pain. Although objective physical performance was preserved, subjective locomotive function was impaired. Therefore, early therapeutic intervention and a multifaceted approach addressing not only physical function but also pain are necessary for women with POI/EM.

Indexed as

MenopauseMenopause, PrematureMusculoskeletal DiseasesMusculoskeletal PainOsteoarthritis, KneePrimary Ovarian InsufficiencyAdultArthralgiaCross-Sectional StudiesFemaleHumansIndependent LivingJapanMiddle AgedPain MeasurementPrevalenceLocomotive syndromeMenopauseMusculoskeletal disorderNeuropathic painPremature ovarian insufficiency

Identifiers

PMID42024254

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.