Evidence map›Paper›PMID 42024243›Full record

ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2026

Simultaneous pallidal and centromedian deep brain stimulation for combined dystonia and drug-resistant epilepsy in a child with hypoxic-ischemic encephalopathy: a technical case report.

Jasmine L Hect, William P Welch, Awa Jobe, Emily Harford, Amit Sinha, Akshay Sharma, Taylor J Abel, Martin G Piazza

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In one paragraph

Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Jasmine L HectDepartment of Neurosurgery, University of Pittsburgh, Pittsburgh, PA, 15224, USA.
William P WelchDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA, 15224, USA.
Awa JobeDepartment of Neurosurgery, University of Pittsburgh, Pittsburgh, PA, 15224, USA.
Emily HarfordDepartment of Neurosurgery, University of Pittsburgh, Pittsburgh, PA, 15224, USA.
Amit SinhaDepartment of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA, 15224, USA.
Akshay SharmaDepartment of Neurosurgery, University of Pittsburgh, Pittsburgh, PA, 15224, USA.
Taylor J AbelDepartment of Neurosurgery, University of Pittsburgh, Pittsburgh, PA, 15224, USA.
Martin G PiazzaDepartment of Neurosurgery, University of Pittsburgh, Pittsburgh, PA, 15224, USA. piazzamg@upmc.edu.

Funding

Intracranial Electrophysiology & Anatomical Connectivity of Voice-Selective Auditory CortexF30DC021342 · NIDCD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Jasmine Leah Hect · 2023 to 2026
$208k
Dystonia Medical Research Foundation DMRF-BCAD-2025-1NIDCD NIH HHS F30DC021342
6 · The paper itself

Abstract

purposeChildren with hypoxic-ischemic encephalopathy (HIE) frequently exhibit both dystonia and drug-resistant generalized epilepsy, reflecting injury to parallel but distinct motor and thalamocortical networks. Deep brain stimulation (DBS) of the globus pallidus internus (GPi) is established for secondary dystonia, and centromedian nucleus (CMN) DBS has recently demonstrated safety and efficacy for Lennox-Gastaut syndrome in the ESTEL trial. We describe the technical feasibility of simultaneous bilateral GPi and CMN DBS in an 8-year-old boy with HIE.

methodsFour DBS leads were implanted in one session using robotic stereotaxy, targeting bilateral GPi and CMN via a combination of direct and indirect targeting. Perioperative workflow, early postoperative findings, and initial programming are detailed.

resultsPostoperative imaging confirmed accurate placement of the leads. GPi leads were turned on prior to discharge on postoperative day 1 without side effects. At 3 weeks post-op, the patient presented with well-healed incisions and subjective improvement in lower extremity tone. The CMN system was activated successfully at the first programming visit.

conclusionDual-target DBS is feasible and safe in pediatric patients. This approach permits simultaneous modulation of non-overlapping basal-ganglia and thalamocortical circuits underlying dystonia and generalized epilepsy.

Indexed as

Deep Brain StimulationDrug Resistant EpilepsyDystoniaHypoxia-Ischemia, BrainChildGlobus PallidusHumansIntralaminar Thalamic NucleiMaleCentromedian thalamusDeep brain stimulationDystoniaEpilepsyPallidumPediatric neurosurgery

Identifiers

PMID42024243

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.