Evidence map›Paper›PMID 42024152›Full record

ArticleEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society2026

Long-term renal function after high-grade renal trauma: a nuclear imaging based cohort study.

Mehul Saxena, Yadvendra Dheer, Shubhajeet Roy, Utkarsh Singh, Satyawati Deswal, Narendra Kumar, Anita Singh, Vaibhav Jaiswal, Samir Misra, Sandeep Tiwari and 3 more

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Article in European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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13 authors.

Mehul SaxenaFaculty of Medical Sciences, King George's Medical University, Lucknow, India.
Yadvendra DheerDepartment of Trauma Surgery, King George's Medical University, Lucknow, India. yadusingh0071@gmail.com.
Shubhajeet RoyGandhi Memorial and Associated Hospitals, King George's Medical University, Lucknow, India.
Utkarsh SinghGandhi Memorial and Associated Hospitals, King George's Medical University, Lucknow, India.
Satyawati DeswalDepartment of Nuclear Medicine, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, India.
Narendra KumarDepartment of Trauma Surgery, King George's Medical University, Lucknow, India.
Anita SinghDepartment of Trauma Surgery, King George's Medical University, Lucknow, India.
Vaibhav JaiswalDepartment of Trauma Surgery, King George's Medical University, Lucknow, India.
Samir MisraDepartment of Trauma Surgery, King George's Medical University, Lucknow, India.
Sandeep TiwariDepartment of Trauma Surgery, King George's Medical University, Lucknow, India.
Aastha UpadhyayDepartment of Nuclear Medicine, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, India.
Md Kaif KhanFaculty of Medical Sciences, King George's Medical University, Lucknow, India.
Mohammed AhsanFaculty of Medical Sciences, King George's Medical University, Lucknow, India.

Funding

King George's Medical University, Lucknow Ref: 523/R-Cell-23, dated 06/07/23
6 · The paper itself

Abstract

purposeRenal trauma constitutes approximately 1% of all trauma cases, yet data on long-term renal function following severe injury remain scarce. This study aimed to evaluate long-term functional and morphological outcomes in patients sustaining Grade 3 or higher renal trauma, and to identify predictors of residual renal function using nuclear imaging.

methodsThis retrospective study included patients with Grade ≥ 3 renal injuries who presented for follow-up ≥ 6 months after trauma at a tertiary care centre between January 2018 and June 2023. Patients with nephrectomy or comorbidities affecting renal function were excluded. Serum renal function tests, DTPA scans (differential GFR), and DMSA scans (cortical morphology and dye uptake) were performed. Multivariable linear regression was used to determine predictors of residual function based on injury grade, gender, and duration of follow-up.

resultsThirty-six patients (mean age 20.50 ± 12.08 years; 75% male) were included with equal representation across Grades 3–5. Mean follow-up was 35.92 ± 18.09 months. The affected kidney demonstrated reduced function (mean GFR 24.96 ± 12.50 mL/min; split function 31.83 ± 12.69%; dye uptake 35.71 ± 13.40%). Grade 5 injuries were significantly associated with lower differential GFR and dye uptake (p < 0.01), while longer follow-up duration and female sex predicted better renal recovery (p < 0.01). Scarring was observed in 66.7% and contraction in 41.7% of affected kidneys.

conclusionSevere (Grade 5) renal injuries are associated with marked and likely irreversible functional loss, whereas Grade 3–4 injuries demonstrate gradual improvement over time. Nuclear imaging offers valuable long-term assessment, and predictive equations derived from clinical variables may aid functional estimation in resource-limited settings.

Indexed as

KidneyAdolescentAdultFemaleGlomerular Filtration RateHumansInjury Severity ScoreKidney Function TestsMaleRadionuclide ImagingRetrospective StudiesYoung AdultDMSA scanDTPA scanKidney injuryLong-term outcomeNuclear imagingRenal traumaTrauma surgery

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