ArticleJournal of Alzheimer's disease : JAD2026
Evaluating self- and informant-reported complaints as predictors of cognitive progression in subjective cognitive decline: A clinically-based evaluation.
Article in Journal of Alzheimer's disease : JAD, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BackgroundSubjective cognitive complaints (SCCs) in cognitively normal older adults are associated with increased dementia risk. However, it remains uncertain which complaints best predict cognitive decline and whether predictive value differs between patient and informant reports.ObjectiveTo examine associations between self- and informant-reported total scores and individual items from the Questionnaire of Cognitive Complaints (QPC) and longitudinal cognitive decline in individuals with subjective cognitive decline (SCD).Methods261 individuals with SCD from the prospective Czech Brain Aging Study were followed longitudinally (mean 4.2-year follow-up). Linear mixed-effects models (random intercepts), adjusted for age, sex, and education, were estimated separately for self- and informant-reported QPC-total scores and for individual QPC-items to examine associations with change over time in global cognition, memory, and executive function/processing speed cognitive composites.ResultsHigher QPC-total scores predicted steeper decline across all cognitive composites in both self- and informant-reports, with modest effects. At the item level, after Bonferroni correction, informant-reported
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