Evidence map›Paper›PMID 42024013›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

A Central Somatic Transmission Mediates Proprioceptive Facilitation of Muscle Pain.

Xiaoyu Zhang, Jiale Yang, Xi Wu, Jie Li, Fujian Lu, Yiman Li, Xingyu Du, Rong Huang, Jamila Asgar, Jing Wang and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Xiaoyu ZhangCentral Laboratory, Peking University School and Hospital of Stomatology, Institute of Molecular Medicine and Peking-Tsinghua Center for Life Sciences, State Key Laboratory of Membrane Biology and Beijing Key Laboratory of Cardiometabolic Molecular Medicine, PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China.
Jiale YangDepartment of Neural and Pain Sciences, School of Dentistry; Program in Neuroscience, Center to Advance Chronic Pain Research, University of Maryland, Baltimore, Maryland, USA.
Xi WuCentral Laboratory, Peking University School and Hospital of Stomatology, Institute of Molecular Medicine and Peking-Tsinghua Center for Life Sciences, State Key Laboratory of Membrane Biology and Beijing Key Laboratory of Cardiometabolic Molecular Medicine, PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China.
Jie LiCentral Laboratory, Peking University School and Hospital of Stomatology, Institute of Molecular Medicine and Peking-Tsinghua Center for Life Sciences, State Key Laboratory of Membrane Biology and Beijing Key Laboratory of Cardiometabolic Molecular Medicine, PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China.
Fujian LuCentral Laboratory, Peking University School and Hospital of Stomatology, Institute of Molecular Medicine and Peking-Tsinghua Center for Life Sciences, State Key Laboratory of Membrane Biology and Beijing Key Laboratory of Cardiometabolic Molecular Medicine, PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China.
Yiman LiCentral Laboratory, Peking University School and Hospital of Stomatology, Institute of Molecular Medicine and Peking-Tsinghua Center for Life Sciences, State Key Laboratory of Membrane Biology and Beijing Key Laboratory of Cardiometabolic Molecular Medicine, PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China.
Xingyu DuCentral Laboratory, Peking University School and Hospital of Stomatology, Institute of Molecular Medicine and Peking-Tsinghua Center for Life Sciences, State Key Laboratory of Membrane Biology and Beijing Key Laboratory of Cardiometabolic Molecular Medicine, PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China.
Rong HuangCentral Laboratory, Peking University School and Hospital of Stomatology, Institute of Molecular Medicine and Peking-Tsinghua Center for Life Sciences, State Key Laboratory of Membrane Biology and Beijing Key Laboratory of Cardiometabolic Molecular Medicine, PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China.
Jamila AsgarDepartment of Neural and Pain Sciences, School of Dentistry; Program in Neuroscience, Center to Advance Chronic Pain Research, University of Maryland, Baltimore, Maryland, USA.
Jing WangDepartment of Neural and Pain Sciences, School of Dentistry; Program in Neuroscience, Center to Advance Chronic Pain Research, University of Maryland, Baltimore, Maryland, USA.
Ke RenDepartment of Neural and Pain Sciences, School of Dentistry; Program in Neuroscience, Center to Advance Chronic Pain Research, University of Maryland, Baltimore, Maryland, USA.
Feipeng ZhuCentral Laboratory, Peking University School and Hospital of Stomatology, Institute of Molecular Medicine and Peking-Tsinghua Center for Life Sciences, State Key Laboratory of Membrane Biology and Beijing Key Laboratory of Cardiometabolic Molecular Medicine, PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China.
Changhe WangCentral Laboratory, Peking University School and Hospital of Stomatology, Institute of Molecular Medicine and Peking-Tsinghua Center for Life Sciences, State Key Laboratory of Membrane Biology and Beijing Key Laboratory of Cardiometabolic Molecular Medicine, PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China.
Yehua GanCentral Laboratory, Peking University School and Hospital of Stomatology, Institute of Molecular Medicine and Peking-Tsinghua Center for Life Sciences, State Key Laboratory of Membrane Biology and Beijing Key Laboratory of Cardiometabolic Molecular Medicine, PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China.
Feng WeiDepartment of Neural and Pain Sciences, School of Dentistry; Program in Neuroscience, Center to Advance Chronic Pain Research, University of Maryland, Baltimore, Maryland, USA.
Zhuan ZhouCentral Laboratory, Peking University School and Hospital of Stomatology, Institute of Molecular Medicine and Peking-Tsinghua Center for Life Sciences, State Key Laboratory of Membrane Biology and Beijing Key Laboratory of Cardiometabolic Molecular Medicine, PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China.ORCID https://orcid.org/0000-0001-9048-6638

Funding

Fundamental Research Funds for the Central Universities PKU2022LCXQ024National Basic Research Program of China 2012CB518006National Basic Research Program of China 2016YFA0500401National Natural Science Foundation of China 21790390National Natural Science Foundation of China 21790394National Natural Science Foundation of China 31327901National Natural Science Foundation of China 31330024National Natural Science Foundation of China 31521062National Natural Science Foundation of China 31600950National Natural Science Foundation of China 31670843National Natural Science Foundation of China 31761133016National Natural Science Foundation of China 32171233National Natural Science Foundation of China 32525031Natural Science Foundation of Shaanxi Province of China 2019JC-07Natural Science Foundation of Shaanxi Province of China 2021TD-37Natural Science Foundation of Shaanxi Province of China 2023-ZDLSF-23NIH/NINDS DE024220NIH/NINDS NS 091296Sanqin Talent Special Support Program SYLTD-S02the 2024 Sanya Science and Technology Special Fund 2024KJFX084
6 · The paper itself

Abstract

Proprioception, often described as a sixth sense to perceive body position and muscle contraction, has been increasingly implicated in the development and maintenance of chronic pain, yet the underlying mechanisms remain unclear. Here, we identify the functional expression of TRPA1 in proprioceptive mesencephalic trigeminal nucleus (MeV) neurons in a mouse model of orofacial muscle pain. TRPA1 sensitization enhances somatic secretion from MeV neurons, thereby promoting the progression and persistence of inflammatory pain by disinhibiting descending pain control from the neighboring noradrenergic locus coeruleus (LC

Indexed as

Facial PainProprioceptionTrigeminal NucleiTRPA1 Cation ChannelAnimalsDisease Models, AnimalLocus CoeruleusMaleMiceTRPA1 Cation ChannelTrpa1 protein, mouseGABAinflammationlocus coeruleusmesencephalic trigeminal nucleusTRPA1

Identifiers

PMID42024013
PMCPMC13285158

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.