Evidence map›Paper›PMID 42023995›Full record

ArticleJournal of clinical pharmacology2026

Effect of Once-Daily Macitentan 75 mg on the Pharmacokinetics of Sildenafil, Riociguat, or Rosuvastatin in Healthy Male Participants.

Dénes Csonka, Cynthia Gargano, Navin Goyal, Marc De Meulder, Vitaly Yartsev, Juan Jose Perez Ruixo

Abstract readClinical Trial, Phase I
In one paragraph

Article in Journal of clinical pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dénes CsonkaJohnson & Johnson, Allschwil, Switzerland.
Cynthia GarganoJohnson and Johnson, Spring House, PA, USA.
Navin GoyalJohnson & Johnson, Raritan, NJ, USA.
Marc De MeulderJohnson & Johnson, Beerse, Belgium.
Vitaly YartsevJohnson & Johnson, Allschwil, Switzerland.
Juan Jose Perez RuixoJohnson & Johnson, Beerse, Belgium.

Funding

Johnson and Johnson
6 · The paper itself

Abstract

Macitentan is an oral, dual ET

Indexed as

Endothelin Receptor AntagonistsPyrazolesPyrimidinesRosuvastatin CalciumSildenafil CitrateSulfonamidesAdultArea Under CurveCytochrome P-450 CYP3ADrug Administration ScheduleDrug InteractionsHealthy VolunteersHumansMaleMiddle AgedYoung AdultCYP3A4 protein, humanCytochrome P-450 CYP3AEndothelin Receptor AntagonistsmacitentanPyrazolesPyrimidinesriociguatRosuvastatin CalciumSildenafil CitrateSulfonamidesdrug interactionsmacitentanpulmonary arterial hypertensionriociguatrosuvastatinsildenafil

Identifiers

PMID42023995
PMCPMC13104799

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.