Evidence map›Paper›PMID 42023955›Full record

ArticleHuman psychopharmacology2026

Psychopathological Concomitants and Motivations Related to Misuse of Non-Steroidal Anti-Inflammatory Drugs and Paracetamol.

Francesco Saverio Bersani, Elisabeth Prevete, Tommaso Accinni, Simone Montaldo, Irene Pinucci, Annalisa Maraone, Lorenzo Tarsitani, Massimo Pasquini, Claudio Imperatori

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Article in Human psychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Francesco Saverio BersaniDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Rome, Italy.ORCID 0000-0002-7555-8020
Elisabeth PreveteDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Rome, Italy.
Tommaso AccinniDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.ORCID 0000-0002-3092-6475
Simone MontaldoDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Irene PinucciDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Annalisa MaraoneDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.ORCID 0000-0003-2390-4494
Lorenzo TarsitaniDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Massimo PasquiniDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.ORCID 0000-0003-3959-8137
Claudio ImperatoriDepartment of Health and Life Sciences, European University of Rome, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionNon-steroidal anti-inflammatory drugs (NSAIDs) and paracetamol are among the most commonly used medications worldwide. It has been suggested that the misuse of such medications is not uncommon. The objective of the present research was to explore prevalence, reported reasons and psychopathological concomitants related to NSAIDs/paracetamol misuse in a sample of users.

methodsThe sample was made of 346 NSAIDs or paracetamol users (age range: 18-64 years); assessments included the 4-item Perceived Stress Scale (PSS-4), the 10-item version of the Adverse Childhood Experiences International Questionnaire (ACE-IQ-10), the Body Image Concern Inventory (BICI), the Alcohol Use Disorders Identification Test-C (AUDIT-C), and questions related to NSAIDs/paracetamol misuse.

resultsForty-eight individuals (13.9%) were categorized as NSAIDs/paracetamol misusers. A logistic regression model showed that higher scores in AUDIT-C, BICI and ACE-IQ-10, and the use of psychiatric medications, were significantly associated with the likelihood of NSAIDs/paracetamol misuse. Specific reasons related to the misuse are also reported. DISCUSSION: Our findings provide novel insights into the relationship between NSAIDs/paracetamol misuse and psychopathology, with potential clinical implications for prevention and treatment.

Indexed as

AcetaminophenAnti-Inflammatory Agents, Non-SteroidalMotivationAdolescentAdultFemaleHumansMaleMiddle AgedSurveys and QuestionnairesYoung AdultAcetaminophenAnti-Inflammatory Agents, Non-Steroidaladverse childhood experiencesdysmorphic symptomsmental healthnon‐steroidal anti‐inflammatory drugsparacetamolpsychological stresssubstance misuse

Identifiers

PMID42023955
PMCPMC13104796

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.