Evidence map›Paper›PMID 42023951›Full record

ArticleChemistry & biodiversity2026

Isoquercitrin Alleviates 5-Fluorouracil-Induced Intestinal Mucositis in Mice by Modulating Inflammation and Oxidative Stress.

Lázaro de Sousa Fideles, Matheus da Silva Campelo, João Francisco Câmara Neto, Conceição da Silva Martins, João Erivan Façanha Barreto, Ícaro Gusmão Pinto Vieira, Nágila Maria Pontes Silva Ricardo, Gilberto Santos Cerqueira, Maria Elenir Nobre Pinho Ribeiro

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lázaro de Sousa FidelesCenter For Studies in Microscopy and Image Processing, Faculty of Medicine, Department of Morphology, Federal University of Ceará, Porangabuçu Campus, Fortaleza, Ceará, Brazil.ORCID https://orcid.org/0000-0001-5303-9142
Matheus da Silva CampeloLaboratory of Polymers and Materials Innovation, Center of Sciences, Department of Organic and Inorganic Chemistry, Federal University of Ceará, Pici Campus, Fortaleza, Ceará, Brazil.ORCID https://orcid.org/0000-0003-0286-1974
João Francisco Câmara NetoLaboratory of Polymers and Materials Innovation, Center of Sciences, Department of Organic and Inorganic Chemistry, Federal University of Ceará, Pici Campus, Fortaleza, Ceará, Brazil.ORCID https://orcid.org/0000-0002-2678-8188
Conceição da Silva MartinsCenter For Studies in Microscopy and Image Processing, Faculty of Medicine, Department of Morphology, Federal University of Ceará, Porangabuçu Campus, Fortaleza, Ceará, Brazil.ORCID https://orcid.org/0000-0001-8710-1856
João Erivan Façanha BarretoCenter For Studies in Microscopy and Image Processing, Faculty of Medicine, Department of Morphology, Federal University of Ceará, Porangabuçu Campus, Fortaleza, Ceará, Brazil.ORCID https://orcid.org/0000-0003-2971-8481
Ícaro Gusmão Pinto VieiraTechnological Development Park, Federal University of Ceará, Pici Campus, Fortaleza, Ceará, Brazil.ORCID https://orcid.org/0000-0002-0576-3643
Nágila Maria Pontes Silva RicardoLaboratory of Polymers and Materials Innovation, Center of Sciences, Department of Organic and Inorganic Chemistry, Federal University of Ceará, Pici Campus, Fortaleza, Ceará, Brazil.ORCID https://orcid.org/0000-0003-1849-5403
Gilberto Santos CerqueiraCenter For Studies in Microscopy and Image Processing, Faculty of Medicine, Department of Morphology, Federal University of Ceará, Porangabuçu Campus, Fortaleza, Ceará, Brazil.ORCID https://orcid.org/0000-0001-6717-3772
Maria Elenir Nobre Pinho RibeiroLaboratory of Polymers and Materials Innovation, Center of Sciences, Department of Organic and Inorganic Chemistry, Federal University of Ceará, Pici Campus, Fortaleza, Ceará, Brazil.ORCID https://orcid.org/0000-0001-6896-7179

Funding

CAPES 1227/2020CNPq 307756/2025-4Conselho Nacional de Desenvolvimento Científico e Tecnológico
6 · The paper itself

Abstract

This study aimed to evaluate the role of isoquercitrin (ISO) in 5-fluorouracil-induced intestinal mucositis. The animals (6 animals/group) were divided into: vehicle (2% DMSO), 5-fluorouracil (5-FU) and groups receiving ISO (10, 50, or 100 mg/kg). ISO at 100 mg/kg (ISO-100) (232.5 ± 3.8 µm) attenuated the reduction in villus height induced by 5-FU (125.3 ± 1.5 µm) and the reduction in crypt depth in the intestine (ISO-100: 101.7 ± 3.5 µm vs 5-FU: 70.8 ± 1.6 µm; p < 0.05). The jejunum was chosen for assays involving oxidative stress and inflammation. ISO-100 attenuated the mastocytosis (ISO-100: 7.6 ± 0.1 mast cells/field vs 5-FU: 12.5 ± 0.2 mast cells/field; p < 0.05) and goblet cell depletion (ISO-100: 11.0 ± 0.5 cells/field vs 5-FU: 8.0 ± 0.6 cells/field; p < 0.05). The treatment with ISO-100 showed lower levels of MDA and MPO, and increased GSH levels. Administration of celecoxib (selective COX-2 inhibitor) + ISO-100 increased the villus height and the immunohistochemistry showed that ISO-100 + CLX (7.4% ± 0.1%) attenuates the expression of COX-2 in jejunum induced by 5-FU (22.5% ± 0.1%). These results show that ISO-100 attenuates 5-FU-induced intestinal mucositis by modulating the inflammatory process and reducing oxidative stress.

Indexed as

FluorouracilInflammationMucositisOxidative StressQuercetinAnimalsCyclooxygenase 2Dose-Response Relationship, DrugMaleMiceCyclooxygenase 2FluorouracilisoquercitrinQuercetin5‐fluorouracilintestinal mucositisisoquercitrinnatural products

Identifiers

PMID42023951
PMCPMC13104798

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.