Evidence map›Paper›PMID 42023901›Full record

ArticleAngewandte Chemie (International ed. in English)2026

Nano-G

Phuong Thu Tran, Mia Danielsen, Johanna K S Tiemann, Passainte Ibrahim, Søren G F Rasmussen, Xavier Kubiak, Hossein Batebi, Charlène Gadais, Steven Ballet, Peter W Hildebrand and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Phuong Thu TranDepartment of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-8875-3108
Mia DanielsenDepartment of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-1812-7176
Johanna K S TiemannUniversität Leipzig, Medizinische Fakultät, Leipzig, Germany.ORCID 0000-0001-7551-6245
Passainte IbrahimUniversität Leipzig, Medizinische Fakultät, Leipzig, Germany.ORCID 0000-0003-3208-7182
Søren G F RasmussenDepartment of Neuroscience, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-1853-1841
Xavier KubiakDepartment of Neuroscience, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-1359-8131
Hossein BatebiUniversität Leipzig, Medizinische Fakultät, Leipzig, Germany.ORCID 0000-0002-0714-9700
Charlène GadaisResearch Group of Organic Chemistry, Departments of Chemistry and Bioengineering Sciences, Vrije Universiteit Brussel, Brussels, Belgium.ORCID 0000-0002-6061-0420
Steven BalletResearch Group of Organic Chemistry, Departments of Chemistry and Bioengineering Sciences, Vrije Universiteit Brussel, Brussels, Belgium.ORCID 0000-0003-4123-1641
Peter W HildebrandUniversität Leipzig, Medizinische Fakultät, Leipzig, Germany.ORCID 0000-0003-0063-1104
Daniel Sejer PedersenDepartment of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-3926-7047
Jesper Mosolff MathiesenDepartment of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-4251-4416

Funding

Center for Scalable Data Analytics and Artificial Intelligence (ScaDS.AI)Deutsche Forschungsgemeinschaft : CRC1423 421152132Lundbeck Foundation R171-2014-361Lundbeck Foundation R37-A3457Stiftung CharitéVietnam International Education Development (VIED) ScholarshipVrije Universiteit Brussel Strategic Research Program SRP50Vrije Universiteit Brussel Strategic Research Program SRP95
6 · The paper itself

Abstract

G protein-coupled receptors (GPCRs) are involved in most human physiological processes and one of the largest families of approved drug-targeted proteins. Heterotrimeric Gαβɣ proteins bind to the intracellular cavity of the activated receptor mainly through the C-terminal α5 helix of the Gα subunit (GαCT). Modulation of GPCR activity through intracellular GPCR binding sites is emerging. Here we develop highly active Gα

Indexed as

GTP-Binding Protein alpha SubunitsGTP-Binding Protein alpha Subunits, GsPeptidesPeptidomimeticsReceptors, Adrenergic, beta-2Binding SitesHumansProtein BindingGTP-Binding Protein alpha SubunitsGTP-Binding Protein alpha Subunits, GsPeptidesPeptidomimeticsReceptors, Adrenergic, beta-2G‐protein‐coupled receptorsG protein surrogatesmolecular dynamicspeptidomimetics

Identifiers

PMID42023901
PMCPMC13245607

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.