Mechanical deformation inhibits growth and migration of

Kelsey G DeFrates, Junsung Lee, Gissell Jimenez, Jae Won Hwang, Mariana G Pinho, Christopher J Hernandez

Abstract read

In one paragraph

Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kelsey G DeFratesDepartment of Orthopaedic Surgery, University of California, San Francisco, California, USA.ORCID 0000-0002-3485-2477

Junsung LeeDepartment of Orthopaedic Surgery, University of California, San Francisco, California, USA.

Gissell JimenezDepartment of Orthopaedic Surgery, University of California, San Francisco, California, USA.

Jae Won HwangDepartment of Orthopaedic Surgery, University of California, San Francisco, California, USA.

Mariana G PinhoInstituto de Tecnologia Química e Biológica António Xavier, Universidade NOVA de Lisboa, Oeiras, Portugal.ORCID 0000-0002-7132-8842

Christopher J HernandezDepartment of Orthopaedic Surgery, University of California, San Francisco, California, USA.ORCID 0000-0002-0712-6533

Funding

National Science Foundation 2025233National Science Foundation CMMI-2135586

6 · The paper itself

Abstract

Bacteria colonize surfaces in the environment and can also penetrate tissues and materials by entering micro- and nano-scale cracks and pores. IMPORTANCE: Bacteria that colonize materials and tissues within the body can be difficult to remove, even with thorough cleaning and application of antibiotics. Recent studies show that bacteria not only colonize the surfaces of tissues in the body but can also squeeze into naturally occurring pores and channels and thereby gain protection from immune cells and antibiotics. Here, we ask how physical forces and cell growth might enable bacteria to enter small pores within materials. We use microfluidic devices to study the growth and migration of the human pathogenic bacteria,

Indexed as

Staphylococcus aureusCell DivisionMicrofluidicsmicrofluidicsosteomyelitisStaphylococcus aureus

Identifiers

PMID42023834

DOI10.1128/mbio.00194-26

PMCPMC13170230

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.