Evidence map›Paper›PMID 42023742›Full record

ArticleJournal of medicinal chemistry2026

Second-Generation Anti-Tubercular Squaramides Targeting Complex V of the Respiratory Chain of

Nada Mosallam, Paul M O'Neill, Monika Lisauskaitė, Christopher M Woodley, Alison Ardrey, Laura N Jeffreys, Ilinca Memelis, Deepak Almeida, Jin Lee, Paul J Converse and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Nada MosallamDepartment of Chemistry, University of Liverpool, Liverpool L69 7ZD, U.K.
Paul M O'NeillDepartment of Chemistry, University of Liverpool, Liverpool L69 7ZD, U.K.ORCID 0000-0003-4338-0317
Monika LisauskaitėDepartment of Chemistry, University of Liverpool, Liverpool L69 7ZD, U.K.
Christopher M WoodleyDepartment of Chemistry, University of Liverpool, Liverpool L69 7ZD, U.K.ORCID 0000-0003-1311-4288
Alison ArdreyCentre for Drugs & Diagnostics, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, U.K.
Laura N JeffreysCentre for Drugs & Diagnostics, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, U.K.ORCID 0000-0002-0607-6116
Ilinca MemelisCentre for Drugs & Diagnostics, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, U.K.
Deepak AlmeidaCenter for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, United States.
Jin LeeCenter for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, United States.
Paul J ConverseCenter for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, United States.
Daire CantillonCentre for Drugs & Diagnostics, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, U.K.
Eric L NuermbergerCenter for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, United States.
Dirk BaldDepartment of A-LIFE, AIMMS, Faculty of Science, Vrije Universiteit Amsterdam De Boelelaan 1108, Amsterdam 1081 HZ, The Netherlands.
Giancarlo A BiaginiCentre for Drugs & Diagnostics, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, U.K.
W David HongDepartment of Chemistry, University of Liverpool, Liverpool L69 7ZD, U.K.ORCID 0000-0002-0030-3007
Neil G BerryDepartment of Chemistry, University of Liverpool, Liverpool L69 7ZD, U.K.
Gemma L NixonDepartment of Chemistry, University of Liverpool, Liverpool L69 7ZD, U.K.ORCID 0000-0002-9730-0960

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Squaramides (SQA) were reported as potent antituberculosis drugs through inhibition of the mycobacterial enzyme adenosine triphosphate (ATP) synthase, which is critical for ATP synthesis. However, squaramide compounds showed high metabolic clearance (CL) despite their promising potency and selectivity. Herein, we describe lead optimization efforts to improve the potency and metabolic stability of previous lead

Indexed as

Antitubercular AgentsMycobacterium tuberculosisPhenolsAnimalsDiarylquinolinesHumansMiceMicrobial Sensitivity TestsQuinineStructure-Activity RelationshipTuberculosisAntitubercular AgentsbedaquilineDiarylquinolinesPhenolsQuininesquaramide

Identifiers

PMID42023742
PMCPMC13181789

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.