Evidence map›Paper›PMID 42023677›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Diabetes, hyperglycemia, and ATN blood biomarkers in Hispanic/Latino populations: SOL-INCA study.

Kevin A González, Wassim Tarraf, Judy Pa, Sarah J Banks, Katherine J Bangen, Douglas Galasko, Linda C Gallo, Ariana M Stickel, Natasha Z Anita, Freddie Márquez and 7 more

Abstract read
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In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Kevin A GonzálezDepartment of Neurosciences and Shiley-Marcos Alzheimer's Disease Research Center, University of California San Diego School of Medicine, San Diego, California, USA.
Wassim TarrafDepartment of Healthcare Sciences and Institute of Gerontology, Wayne State University, Detroit, Michigan, USA.
Judy PaDepartment of Neurosciences and Shiley-Marcos Alzheimer's Disease Research Center, University of California San Diego School of Medicine, San Diego, California, USA.
Sarah J BanksDepartment of Neurosciences and Shiley-Marcos Alzheimer's Disease Research Center, University of California San Diego School of Medicine, San Diego, California, USA.
Katherine J BangenDepartment of Psychiatry, University of California San Diego School of Medicine, San Diego, California, USA.
Douglas GalaskoDepartment of Neurosciences and Shiley-Marcos Alzheimer's Disease Research Center, University of California San Diego School of Medicine, San Diego, California, USA.
Linda C GalloDepartment of Psychology and South Bay Latino Research Center, San Diego State University, San Diego, California, USA.
Ariana M StickelDepartment of Psychology and South Bay Latino Research Center, San Diego State University, San Diego, California, USA.
Natasha Z AnitaDepartment of Neurosciences and Shiley-Marcos Alzheimer's Disease Research Center, University of California San Diego School of Medicine, San Diego, California, USA.
Freddie MárquezDepartment of Neurosciences and Shiley-Marcos Alzheimer's Disease Research Center, University of California San Diego School of Medicine, San Diego, California, USA.
Paola FiligranaDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USA.
Carmen R IsasiDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USA.
Martha DaviglusInstitute for Minority Health Research, University of Illinois at Chicago, College of Medicine, Chicago, Illinois, USA.
Fernando D TestaiDepartment of Neurology and Rehabilitation, University of Illinois Chicago, Chicago, Illinois, USA.
Melissa LamarInstitute for Minority Health Research, University of Illinois at Chicago, College of Medicine, Chicago, Illinois, USA.
Charles DeCarliDepartment of Neurology, University of California, Davis, Sacramento, California, USA.
Hector M GonzálezDepartment of Neurosciences and Shiley-Marcos Alzheimer's Disease Research Center, University of California San Diego School of Medicine, San Diego, California, USA.ORCID 0000-0003-4867-7902

Funding

Study of Latinos-Investigation of Neurocognitive Aging-Alzheimer's diseaseR01AG075758 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Charles DeCarli, Hector M Gonzalez · 2022 to 2026
$21.7M
MRI Measures of Cerebrovascular Injury and AD Atrophy in a Study of LatinosRF1AG054548 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DECARLI, CHARLES, GONZALEZ, HECTOR M · 2017 to 2017
$14.7M
Study of Latinos Investigation of Neurocognitive Aging 2R56AG048642 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DECARLI, CHARLES, GONZALEZ, HECTOR M · 2020 to 2021
$8.7M
Neurocognitive aging, MCI and Alzheimer's disease DNA methylation among diverse LatinosRF1AG061022 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FORNAGE, MYRIAM, GONZALEZ, HECTOR M · 2019 to 2019
$6.6M
Albert Einstein College of Medicine HHSN268201300002I/N01-HC-65235National Heart, Lung and Blood InstituteNational Science Foundation Graduate Research Fellowship ProgramNIA NIH HHS R01AG075758NIA NIH HHS R56AG048642NIA NIH HHS RF1AG054548NIA NIH HHS RF1AG061022NIDCD NIH HHSNIDCR NIH HHSNIDDK NIH HHSNIMHD NIH HHSNINDS NIH HHSOffice of Dietary SupplementsSan Diego State University HHSN268201300005I / N01-HC-65237University of Illinois at Chicago HHSN268201300003I / N01- HC-65236University of Miami HHSN268201300004I / N01-HC-65234University of North Carolina HHSN268201300001I / N01-HC-65233
6 · The paper itself

Abstract

introductionResearch studying associations between plasma amyloid-tau-neurodegeneration (ATN) biomarkers and vascular factors, such as diabetes, is limited. We sought to examine associations between diabetes status and plasma ATN biomarkers in diverse Hispanic/Latino individuals.

methodsWe used data from the Hispanic Community Health Study/Study of Latinos and the Study of Latinos-Investigation of Neurocognitive Aging ancillary studies. Our exposures included diabetes status and hemoglobin A1c (HbA1c) percentage. Outcomes included amyloid beta (Aβ) 42/40 ratio, phosphorylated tau 181 (p-tau181), neurofilament light chain (NfL), and glial fibrillary acidic protein (GFAP).

resultsThe final analytic sample was N = 6264. Diabetes, but not prediabetes, was associated with higher NfL and p-tau181 and lower Aβ42/40 ratio. Elevated HbA1c percentage was associated with higher NfL, p-tau181, and GFAP and lower Aβ42/40. DISCUSSION: Diabetes was associated with plasma biomarkers of Alzheimer's disease pathology and non-specific neurodegeneration. Reducing diabetes prevalence could be beneficial for lowering dementia risk in this population.

Indexed as

Amyloid beta-PeptidesDiabetes MellitusHispanic or LatinoHyperglycemiatau ProteinsAgedBiomarkersFemaleGlial Fibrillary Acidic ProteinGlycated HemoglobinHumansMaleMiddle AgedNeurofilament ProteinsPeptide FragmentsAmyloid beta-Peptidesamyloid beta-protein (1-40)amyloid beta-protein (1-42)BiomarkersGFAP protein, humanGlial Fibrillary Acidic ProteinGlycated Hemoglobinhemoglobin A1c protein, humanneurofilament protein LNeurofilament ProteinsPeptide Fragmentstau ProteinsamyloidATN biomarkersdiabetesglial fibrillary acidic proteinLatinosneurofilament light chaintau

Identifiers

PMID42023677
PMCPMC13104098

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.