Evidence map›Paper›PMID 42023626›Full record

Observational studyPediatric endocrinology, diabetes, and metabolism2026

Ketoacidosis in new-onset type 1 diabetes: return to pre-COVID-19 pandemic reality?

Rita Gomes Alvelos, Paula Santos, Mariana Sebastião, Catarina Tavares, Inês Barros Rua, Joana Serra-Caetano, Rita Cardoso, Isabel Dinis, Alice Mirante

Abstract readComparative StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Pediatric endocrinology, diabetes, and metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rita Gomes AlvelosDepartment of Paediatrics, Unidade Local de Saúde Região de Aveiro, Portugal. 72169@chbv.min-saude.pt.
Paula SantosPaediatric Endocrinology, Diabetes and Growth Unit, Hospital Pediátrico de Coimbra, Unidade Local de Saúde de Coimbra, Portugal.
Mariana SebastiãoPaediatric Endocrinology, Diabetes and Growth Unit, Hospital Pediátrico de Coimbra, Unidade Local de Saúde de Coimbra, Portugal.
Catarina TavaresPaediatric Endocrinology, Diabetes and Growth Unit, Hospital Pediátrico de Coimbra, Unidade Local de Saúde de Coimbra, Portugal.
Inês Barros RuaPaediatric Endocrinology, Diabetes and Growth Unit, Hospital Pediátrico de Coimbra, Unidade Local de Saúde de Coimbra, Portugal.
Joana Serra-CaetanoPaediatric Endocrinology, Diabetes and Growth Unit, Hospital Pediátrico de Coimbra, Unidade Local de Saúde de Coimbra, Portugal.
Rita CardosoPaediatric Endocrinology, Diabetes and Growth Unit, Hospital Pediátrico de Coimbra, Unidade Local de Saúde de Coimbra, Portugal.
Isabel DinisPaediatric Endocrinology, Diabetes and Growth Unit, Hospital Pediátrico de Coimbra, Unidade Local de Saúde de Coimbra, Portugal.
Alice MirantePaediatric Endocrinology, Diabetes and Growth Unit, Hospital Pediátrico de Coimbra, Unidade Local de Saúde de Coimbra, Portugal.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionType 1 diabetes mellitus (T1D) is one of the most common chronic diseases in childhood, with its incidence increasing globally. The coronavirus disease 2019 (COVID-19) pandemic has been associated with an increase in severity of cases of diabetic ketoacidosis. AIM OF THE STUDY: Type 1 diabetes mellitus (T1D) is one of the most common chronic diseases in childhood, with its incidence increasing globally. The coronavirus disease 2019 (COVID-19) pandemic has been associated with an increase in severity of cases of diabetic ketoacidosis. MATERIAL AND

methodsA retrospective cohort study was conducted, using patients' clinical records, between March 2016 and March 2024. The sample was divided in three groups: pre-pandemic (March 2016 to March 2020), pandemic (March 2020 to March 2021), and post-pandemic (March 2021 to March 2024).

resultsA retrospective cohort study was conducted, using patients' clinical records, between March 2016 and March 2024. The sample was divided in three groups: pre-pandemic (March 2016 to March 2020), pandemic (March 2020 to March 2021), and post-pandemic (March 2021 to March 2024).

conclusionsThere was an improvement in the post-pandemic period, with a lower severity at presentation. However, the rate of ketoacidosis remained high, and the focus must remain on implementing preventative measures.

Indexed as

COVID-19Diabetes Mellitus, Type 1Diabetic KetoacidosisPandemicsChildFemaleHumansIncidenceMaleRetrospective StudiesSeverity of Illness IndexCOVID-19.diabetes mellitus type 1diabetic ketoacidosis

Identifiers

PMID42023626
PMCPMC13153753

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.