Evidence map›Paper›PMID 42023587›Full record

ArticleThe American journal of surgical pathology2026

Hidradenoma in Axillary Lymph Nodes: A Diagnostic Pitfall Mimicking Metastatic Carcinoma.

Gregory R Bean, Leandra G Kingsley, Jennifer Tan, Cooper D Rutland, Rachel Lin, Julia A Bridge, Paras B Patel, Poonam Vohra, Gregor Krings, Yunn-Yi Chen

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In one paragraph

Article in The American journal of surgical pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Gregory R BeanDepartment of Pathology, Stanford University School of Medicine, Stanford, CA.ORCID 0000-0003-2866-8283
Leandra G KingsleyDepartment of Pathology, Stanford University School of Medicine, Stanford, CA.
Jennifer TanDepartment of Pathology, Stanford University School of Medicine, Stanford, CA.
Cooper D RutlandDepartment of Pathology, Stanford University School of Medicine, Stanford, CA.
Rachel LinDepartment of Pathology, University of California San Francisco, San Francisco, CA.
Julia A BridgeDepartment of Pathology, University of Utah, ARUP, Salt Lake City, UT.
Paras B PatelProPath, Dallas, TX.
Poonam VohraDepartment of Pathology, University of California San Francisco, San Francisco, CA.
Gregor KringsDepartment of Pathology, Diagnostics Institute, Cleveland Clinic, Cleveland, OH.
Yunn-Yi ChenDepartment of Pathology, University of California San Francisco, San Francisco, CA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Axillary lymph nodes are a common site of metastatic carcinoma, particularly from the breast. Epithelial inclusions within axillary lymph nodes are uncommon but well recognized, most frequently encountered as small, incidental clusters of mammary-type epithelium; squamous, Müllerian, and mixed types are also sporadically identified. Hidradenoma is a benign adnexal neoplasm classically composed of epidermoid/squamoid, intermediate/basaloid, and mucinous cells that most commonly originates in the skin but can arise in the breast parenchyma, with morphologic and genetic features that overlap with mucoepidermoid carcinoma. Rare instances of hidradenomas within pelvic and axillary lymph nodes have been reported, raising the specter of metastasis. We report 3 cases of axillary lymph node hidradenoma presenting without a concurrent breast or cutaneous lesion. Morphology, immunohistochemistry, and molecular studies were evaluated. Two cases were found to harbor CRTC1::MAML2 rearrangements, while a rarer CRTC3::MAML2 fusion was identified in a third case. Following excision, the 3 patients were without evidence of residual disease, with clinical follow-up of ∼2 years each. Recognition of this entity is essential to avoid misclassification as metastatic carcinoma and prevent overtreatment.

Indexed as

AcrospiromaAdenoma, Sweat GlandCarcinomaLymph NodesSweat Gland NeoplasmsAdultAxillaBiomarkers, TumorBiopsyDiagnosis, DifferentialFemaleGene RearrangementHumansImmunohistochemistryLymphatic MetastasisLymph Node ExcisionBiomarkers, Tumoraxillary lymph nodebreast cancerhidradenomainclusion

Identifiers

PMID42023587
PMCPMC13361949

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.