ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
The relative contribution of modifiable and non-modifiable factors for determining cognition in mid-life individuals at risk for late-life Alzheimer's disease.
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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12 authors.
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Abstract
introductionIt remains unknown whether cognitive reserve contributors can protect against dementia from mid-life, in the context of several modifiable and non-modifiable risk factors, including family history and inherited risk for late-life dementia.
methodsWe leveraged PREVENT Dementia, a large multisite study of healthy mid-life at-risk individuals (
resultsThe CCA identified a significant canonical mode ( DISCUSSION: These results highlight the strong potential of early, cost-effective, and multifactorial dementia prevention interventions that target both modifiable risk reduction and boosting of cognitive reserve from mid-life.
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