ArticleFrontiers in pediatrics2026
Neonatal-onset cyanotic breath-holding spells: a case report with longitudinal diagnostic dilemma.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Breath-holding spells (BHS) are benign paroxysmal events that typically present between 6 and 18 months of age. Neonatal-onset BHS is rare and may closely mimic other causes of neonatal cyanotic episodes, particularly respiratory inhibition after crying (RIAC). We report a term male infant who developed recurrent cyanotic episodes starting at birth and underwent extensive investigations with unremarkable results. He was initially diagnosed with prolonged RIAC. Longitudinal follow-up demonstrated persistence of episodes with evolution into a classical cyanotic breath-holding phenotype. This case highlights the importance of longitudinal assessment in neonates with unexplained cyanotic spells and supports the inclusion of breath-holding spells in the differential diagnosis after exclusion of serious underlying conditions.
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