ReviewFrontiers in pediatrics2026
Maternal risk factors for biliary atresia in neonates: a systematic review and meta-analysis.
Review in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: The risk factors for neonatal biliary atresia remain unclear. This study aimed to systematically analyze maternal risk factors associated with the development of neonatal biliary atresia (BA). Methods: A systematic search was conducted in PubMed, Embase, Web of Science, and the Cochrane Library to retrieve relevant literature published from database inception to December 31, 2025, focusing on maternal risk factors for neonatal biliary atresia. Stata (Version 18.0) was used for meta-analysis. Results: A total of 10 retrospective studies were included in the meta-analysis. The results identified several statistically significant risk factors for the development of biliary atresia (BA), including maternal urogenital tract infection (OR = 1.21, 95% CI: 1.02-1.43), maternal diabetes mellitus (OR = 1.55, 95% CI: 1.20-2.00), preterm birth (OR = 2.64, 95% CI: 1.66-4.22), and low birth weight (OR = 1.66, 95% CI: 1.28-2.16). Additionally, the incidence of BA was significantly lower in neonates of White/Caucasian ethnicity (OR = 0.67, 95% CI: 0.46-0.98). By contrast, maternal smoking history, neonatal sex, maternal age (with 35 years as the cutoff), mode of delivery, and fetal number (singleton/multiple pregnancy) did not show statistically significant associations in this meta-analysis. Conclusion: The pathogenesis of neonatal biliary atresia is associated with multiple factors, including genetics, intrauterine infection, and maternal environmental exposures. Heightened vigilance for biliary atresia in neonates with high-risk characteristics is warranted to facilitate early diagnosis and treatment. However, due to the limited number of included studies, our findings require further validation through research with larger sample sizes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.