Evidence map›Paper›PMID 42023257›Full record

ArticleIbrain2026

RETRACTED: Clinical effectiveness and treatment satisfaction between two triple-therapy regimens in treating neuropathic pain: A real-world data.

Nithya Raju, Samyuktha Villavan, Saranya Ravi, Roja Murugesan, Panneerselvam Theivendren, Vennila Jaganathan, Redlin Jani Rajan, Krupanidhi Karunanithi

RetractedAbstract readRetracted Publication
In one paragraph

Article in Ibrain, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Nithya RajuDepartment of Pharmacy Practice Swamy Vivekanandha College of Pharmacy Namakkal India.ORCID https://orcid.org/0000-0003-1535-1404
Samyuktha VillavanDepartment of Pharmacy Practice Swamy Vivekanandha College of Pharmacy Namakkal India.ORCID https://orcid.org/0009-0005-0407-3332
Saranya RaviDepartment of Pharmacy Practice Swamy Vivekanandha College of Pharmacy Namakkal India.ORCID https://orcid.org/0009-0004-9870-3085
Roja MurugesanDepartment of Pharmacy Practice Swamy Vivekanandha College of Pharmacy Namakkal India.ORCID https://orcid.org/0009-0008-4136-2995
Panneerselvam TheivendrenDepartment of Pharmaceutical Chemistry Swamy Vivekanandha College of Pharmacy Namakkal India.ORCID 0000-0002-8197-4688
Vennila JaganathanDepartment of Statistics, Manipal College of Health Professions Manipal Academy of Higher Education Manipal India.ORCID https://orcid.org/0000-0002-6472-6631
Redlin Jani RajanDepartment of Pharmacy Practice Swamy Vivekanandha College of Pharmacy Namakkal India.ORCID https://orcid.org/0000-0002-3072-0282
Krupanidhi KarunanithiDepartment of Emergency Medicine Swamy Vivekanandha Medical College Hospital and Research Institute Namakkal India.ORCID https://orcid.org/0000-0001-8714-4477

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Triple-therapy regimens involving Pregabalin or Gabapentin with nortriptyline and Methylcobalamin have been shown to be efficacious in treating neuropathic pain in clinical trials. This study aims to compare the clinical effectiveness and treatment satisfaction of two triple-therapy regimens in treating neuropathic pain in a real-world setting. This prospective, single-center, observational study compared the efficacy, safety, and treatment satisfaction of triple therapy in Pregabalin triple therapy versus Gabapentin triple therapy for patients with neuropathic pain. The primary outcome measured the reduction in mean Self-Administered Leeds Assessment of Neuropathic Symptoms and Signs pain score value from the baseline to 12 weeks posttreatment. The secondary outcome measured the treatment satisfaction for both therapies using the Treatment Satisfaction Questionnaire for Medication version 1.4. Of 264 patients who received either treatment group, during the third follow-up, it became evident that Group A Pregabalin triple therapy yielded a significantly more substantial reduction in neuropathic pain (60.61%) when compared to Group B Gabapentin triple therapy (12.88%). Furthermore, patients expressed markedly higher levels of satisfaction and convenience with the Pregabalin treatment (

Indexed as

Gabapentingabapentin triple therapyneuropathic painpregabalin triple therapyTreatment Satisfaction Questionnaire for Medication

Identifiers

PMID42023257
PMCPMC13097625

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.