ArticleFrontiers in immunology2026
Favorable short-term survival in locally advanced cervical cancer with optimal pathological response after neoadjuvant chemoimmunotherapy: a real-world analysis.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: This real-world study evaluated short-term survival outcomes and potential risk factors in patients with locally advanced cervical cancer (LACC) who achieved optimal pathological response (OPR) following neoadjuvant chemoimmunotherapy and radical surgery. Methods: A retrospective analysis was conducted on LACC patients treated at a high-volume tertiary medical system between 2022 and 2025. All eligible patients received neoadjuvant chemoimmunotherapy followed by radical hysterectomy. Pathological response was categorized as pathological complete response (pCR; no residual tumor) or major pathological response (MPR; ≤10% residual tumor). Clinical data, treatment details, and follow-up information were systematically collected. Additionally, transcriptomic profiling and multi-algorithm immune infiltration consensus analyses were performed on matched pre- and post-treatment tumor specimens to uncover treatment-induced microenvironmental remodeling. Results: Among 89 eligible patients who underwent surgery, 32 (35.9%) achieved an OPR, comprising 18 (20.2%) with pCR and 14 (15.7%) with MPR. Over a median follow-up of 13 months, the estimated 2-year disease-free survival was 90.7% with an estimated overall survival of 100%. No specific baseline clinicopathological factor emerged as a significant predictor of recurrence in univariable analysis. The regimen was well-tolerated, with grade 3 treatment-related adverse events occurring in 21.9% and no grade 4-5 events reported. Transcriptomic profiling of 10 paired pCR specimens revealed preliminary microenvironmental remodeling post-treatment, characterized by the activation of the NFAT signaling pathway and extracellular matrix reorganization. Conclusion: LACC patients attaining pCR or MPR after neoadjuvant chemoimmunotherapy and surgery demonstrated excellent short-term survival outcomes. These findings provide a rationale for considering de-escalated adjuvant therapy in this highly responsive subgroup. Validation through larger prospective cohorts with extended follow-up is warranted.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.