Evidence map›Paper›PMID 42023221›Full record

ArticleFrontiers in immunology2026

Therapeutic efficacy of bovine ultra-long CDR H3 antibody against BVDV in challenged BALB/c mouse model.

Gege Rile, Qihuan Zhao, Na Qi, Bo Wang, Jingsi Mei, Hui Wang, Shujun Zhang, Fuxiang Bao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gege Rile *College of Veterinary Medicine, Inner Mongolia Agricultural University, Huhhot, China.
Qihuan Zhao *College of Veterinary Medicine, Inner Mongolia Agricultural University, Huhhot, China.
Na QiSaikexing Breeding Biotechnology (Group) Co., Ltd., Huhhot, China.
Bo WangCollege of Veterinary Medicine, Inner Mongolia Agricultural University, Huhhot, China.
Jingsi MeiCollege of Veterinary Medicine, Inner Mongolia Agricultural University, Huhhot, China.
Hui WangCollege of Veterinary Medicine, Inner Mongolia Agricultural University, Huhhot, China.
Shujun ZhangCollege of Veterinary Medicine, Inner Mongolia Agricultural University, Huhhot, China.
Fuxiang BaoCollege of Veterinary Medicine, Inner Mongolia Agricultural University, Huhhot, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bovine Viral Diarrhea Virus (BVDV), the etiologic agent of bovine viral diarrhea, poses substantial economic threats to the cattle industry worldwide. While vaccination represents the cornerstone of preventive strategies, relying primarily on inactivated whole-virus vaccines, continuous viral evolution has rendered these conventional formulations inadequately protective. Bovine ultralong CDR H3 antibodies, characterized by a 70-amino-acid composition, emerge as promising candidates for therapeutic development. However, their effectiveness against BVDV remains largely unexplored. In this study, a phage display library encoding BVDV-specific ultralong CDR H3 antibodies was successfully constructed and subjected to biopanning. Selected high-affinity antibodies were expressed and purified, and showed specific binding to BVDV with an affinity of 312.5 ng/mL and neutralizing activity (IC

Indexed as

Antibodies, NeutralizingAntibodies, ViralBovine Virus Diarrhea-Mucosal DiseaseComplementarity Determining RegionsDiarrhea Viruses, Bovine ViralAnimalsCattleDisease Models, AnimalFemaleMiceMice, Inbred BALB CViral LoadAntibodies, NeutralizingAntibodies, ViralComplementarity Determining Regionsantibody purificationbovine viral diarrhea virusneutralizing antibodytherapeutic efficacyultralong CDR H3 antibody

Identifiers

PMID42023221
PMCPMC13095820

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.