Evidence map›Paper›PMID 42023150›Full record

ArticleiScience2026

Mechanical activation of PIEZO1 drives AP-1-dependent PTGS2/PGE2 signaling and corneal inflammation.

Zongzheng Zou, Xiuqing Qian, Jifeng Ren, Yuqing Wang, Yuqi Liu, Aojun Luo, Mengyuan Guo, Hui Tong, Ruiran Li, Shanshan Li and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zongzheng ZouSchool of Biomedical Engineering, Capital Medical University, Beijing 100069, China.
Xiuqing QianSchool of Biomedical Engineering, Capital Medical University, Beijing 100069, China.
Jifeng RenSchool of Biomedical Engineering, Capital Medical University, Beijing 100069, China.
Yuqing WangSchool of Biomedical Engineering, Capital Medical University, Beijing 100069, China.
Yuqi LiuSchool of Biomedical Engineering, Capital Medical University, Beijing 100069, China.
Aojun LuoSchool of Biomedical Engineering, Capital Medical University, Beijing 100069, China.
Mengyuan GuoBeijing Institute of Brain Disorders, Capital Medical University, Beijing, China.
Hui TongSchool of Biomedical Engineering, Capital Medical University, Beijing 100069, China.
Ruiran LiSchool of Biomedical Engineering, Capital Medical University, Beijing 100069, China.
Shanshan LiSchool of Biomedical Engineering, Capital Medical University, Beijing 100069, China.
Haixia ZhangSchool of Biomedical Engineering, Capital Medical University, Beijing 100069, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Abnormal mechanical stimulation, such as eye rubbing, is a critical risk factor for corneal diseases, yet the molecular mechanisms linking mechanical stimulation to inflammation remain unclear. Here, we show that mechanical stretch directly activates the mechanosensitive ion channel PIEZO1 in human corneal fibroblasts, leading to Ca

Indexed as

cell biologyimmunologytranscriptomics

Identifiers

PMID42023150
PMCPMC13096964

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.