ArticleInternational journal of endocrinology2026
Dynapenic Abdominal Obesity and Cognitive Impairment in Type 2 Diabetic Patients: A Single-Center Cross-Sectional Study.
Article in International journal of endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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- Dynapenic Abdominal Obesity and Cognitive Impairment in Type 2 Diabetic Patients: A Single-Center Cross-Sectional Study.International journal of endocrinology · 2026Article
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8 authors.
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Abstract
Background: The relationship between obesity and cognitive dysfunction remains controversial. Dynapenic abdominal obesity (DAO) is characterized by a combination of abdominal obesity and low muscle strength. However, as a unique subtype of obesity, the relationship between DAO and cognitive function in patients with Type 2 diabetes (T2D) is not clear. Materials and Methods: A total of 270 middle-aged and older T2D patients were included in the study and divided into four groups: dynapenic obesity (DO), nondynapenic obesity (NO), dynapenic nonobesity (DN), and nondynapenic nonobesity (NN). Patient demographics, lifestyle habits, metabolic and inflammatory markers, diabetes-related characteristics, grip strength (GS), anthropometry, and Montreal Cognitive Assessment (MoCA) scores were recorded. Multiple linear regression was used to analyze the relationships among GS, waist circumference (WC), DAO, and MoCA scores, and multiple logistic regression was used to identify the factors influencing DAO. Results: Compared with NN patients, patients with DO tended to be older and female. These patients had higher insulin resistance indices and inflammatory indicators, lower hemoglobin levels and estimated glomerular filtration rate (eGFR), and a greater burden of diabetes. In addition, the DO group presented lower gait speeds and greater body fat percentage and limb fat mass. More importantly, they had lower MoCA scores. Notably, DAO and lower GS were associated with lower MoCA scores. The following factors influence DAO: age, gait speed, and diabetic retinopathy. Conclusions: Among middle-aged and older individuals with T2D, DAO is independently associated with cognitive impairment and presents phenotypic features linked to age and diabetes.
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